Adv Pediatr Surg.  2020 Jun;26(1):23-27. 10.13029/aps.2020.26.1.23.

Ganglioneuroblastoma Found on an Infant with Langerhans Cell Histiocytosis after Several Months of Chemotherapy: A Case Report

• Han I
• Byun J
• Han JW
• Kim HY

• KMID: 2525495
• DOI: http://doi.org/10.13029/aps.2020.26.1.23

Abstract

In patients with Langerhans cell histiocytosis (LCH), it is possible for other malignancies to develop. In the majority of cases, these are lymphomas and leukemia; however, in some cases solid tumors such as lung carcinomas may exist concurrently or can develop after chemotherapy. We want to introduce a rare solid tumor that can be found during LCH treatment. A 4-year old boy who was treated for 15 months with chemotherapy for LCH. The mass was noted on a follow-up abdominal ultrasonography. He underwent an abdominal mass excision and it was confirmed as a ganglioneuroblastoma. Coexistence of malignant neoplasms with LCH is currently being studied but is not yet well understood. In this case report, ganglioneuroblastoma appeared after chemotherapy for LCH. Whether this solid tumor developed as a result of chemotherapy or was formed due to the inflammatory response of LCH is still controversial.

Keyword

Histiocytosis; Langerhans-cell; Ganglioneuroblastoma; Drug therapy