J Stroke.  2022 Jan;24(1):41-48. 10.5853/jos.2021.03909.

Mechanical Thrombectomy Access for All? Challenges in Increasing Endovascular Treatment for Acute Ischemic Stroke in the United States

Affiliations
  • 1Department of Neurology, Rutgers New Jersey Medical School, Newark, NJ, USA
  • 2Department of Neurosurgery, University of Illinois and AMITA Health, Chicago, IL, USA
  • 3Society of Vascular and Interventional Neurology, St. Cloud, MN, USA
  • 4University of Miami, Herbert Business School, Miami, FL, USA
  • 5Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada
  • 6Semmes Murphey Clinic, University of Tennessee Health Science Center, Memphis, TN, USA
  • 7Department of Neurology, University of Iowa Hospital and Clinics, Iowa City, IA, USA
  • 8Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA
  • 9Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
  • 10Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA

Abstract

Mechanical thrombectomy (MT) is the most effective treatment for selected patients with an acute ischemic stroke due to emergent large vessel occlusions (LVOs). There is an urgent need to identify and address challenges in access to MT to maximize the numbers of patients who can benefit from this treatment. Barriers in access to MT include delays in evaluation and accurate diagnosis of LVO leading to inappropriate triage, logistical delays related to availability of facilities and trained interventionalists, and financial hurdles that affect treatment reimbursement. Collection of regional data related to these barriers is critical to better understand current access gaps and a measurable access score to thrombectomy could be useful to plan local public health intervention.

Keyword

Stroke; Triage; Public health; Thrombectomy; Ischemic stroke; Healthcare disparities

Figure

  • Figure 1. Factors contributing to delay in the information and diagnostic access leading to decreased odds of good functional outcome (modified Rankin Scale [mRS] 0–2) for mechanical thrombectomy. CTP, computerized tomography perfusion; CSC, comprehensive stroke center; TSC, thrombectomy capable stroke center; EDP, emergency department physician; LVO, large vessel occlusion; CTA, computed tomography angiogram; CT, computed tomography; DIDO, door in-door out; ASRH, acute stroke ready hospital; PSC, primary stroke center; EMS, emergency medical service. *Not to scale.


Reference

References

1. Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016; 387:1723–1731.
Article
2. Albers GW, Lansberg MG, Kemp S, Tsai JP, Lavori P, Christensen S, et al. A multicenter randomized controlled trial of endovascular therapy following imaging evaluation for ischemic stroke (DEFUSE 3). Int J Stroke. 2017; 12:896–905.
Article
3. Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, et al. Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med. 2018; 378:11–21.
4. Kunz WG, Hunink MG, Almekhlafi MA, Menon BK, Saver JL, Dippel DWJ, et al. Public health and cost consequences of time delays to thrombectomy for acute ischemic stroke. Neurology. 2020; 95:e2465–e2475.
Article
5. Nagel S, Bouslama M, Krause LU, Küpper C, Messer M, Petersen M, et al. Mechanical thrombectomy in patients with milder strokes and large vessel occlusions. Stroke. 2018; 49:2391–2397.
Article
6. Sarraj A, Hassan AE, Grotta J, Sitton C, Cutter G, Cai C, et al. Optimizing patient selection for endovascular treatment in acute ischemic stroke (SELECT): a prospective, multicenter cohort study of imaging selection. Ann Neurol. 2020; 87:419–433.
Article
7. Goyal M, Ospel JM, Menon BK, Hill MD. MeVO: the next frontier? J Neurointerv Surg. 2020; 12:545–547.
Article
8. Sarraj A, Grotta JC, Pujara DK, Shaker F, Tsivgoulis G. Triage imaging and outcome measures for large core stroke thrombectomy: a systematic review and meta-analysis. J Neurointerv Surg. 2020; 12:1172–1179.
9. Lakomkin N, Dhamoon M, Carroll K, Singh IP, Tuhrim S, Lee J, et al. Prevalence of large vessel occlusion in patients presenting with acute ischemic stroke: a 10-year systematic review of the literature. J Neurointerv Surg. 2019; 11:241–245.
Article
10. Waqas M, Rai AT, Vakharia K, Chin F, Siddiqui AH. Effect of definition and methods on estimates of prevalence of large vessel occlusion in acute ischemic stroke: a systematic review and meta-analysis. J Neurointerv Surg. 2020; 12:260–265.
Article
11. MacKenzie IER, Moeini-Naghani I, Sigounas D. Trends in endovascular mechanical thrombectomy in treatment of acute ischemic stroke in the United States. World Neurosurg. 2020; 138:e839–e846.
Article
12. Rinaldo L, Rabinstein AA, Cloft H, Knudsen JM, Castilla LR, Brinjikji W. Racial and ethnic disparities in the utilization of thrombectomy for acute stroke. Stroke. 2019; 50:2428–2432.
Article
13. Institute of Medicine (US) Committee on Monitoring Access to Personal Health Care Services. Access to Health Care in America. Washington, DC: National Academies Press (US);1993.
14. Zachrison KS, Li S, Reeves MJ, Adeoye O, Camargo CA, Schwamm LH, et al. Strategy for reliable identification of ischaemic stroke, thrombolytics and thrombectomy in large administrative databases. Stroke Vasc Neurol. 2021; 6:194–200.
Article
15. Ojike N, Ravenell J, Seixas A, Masters-Israilov A, Rogers A, Jean-Louis G, et al. Racial disparity in stroke awareness in the US: an analysis of the 2014 National Health Interview Survey. J Neurol Neurophysiol. 2016; 7:365.
Article
16. Goldstein LB, Silberberg M, McMiller Y, Yaggy SD. Stroke-related knowledge among uninsured Latino immigrants in Durham County, North Carolina. J Stroke Cerebrovasc Dis. 2009; 18:229–231.
Article
17. Reeves MJ, Prager M, Fang J, Stamplecoski M, Kapral MK. Impact of living alone on the care and outcomes of patients with acute stroke. Stroke. 2014; 45:3083–3085.
Article
18. Mochari-Greenberger H, Xian Y, Hellkamp AS, Schulte PJ, Bhatt DL, Fonarow GC, et al. Racial/ethnic and sex differences in emergency medical services transport among hospitalized US stroke patients: analysis of the National Get With The Guidelines-Stroke Registry. J Am Heart Assoc. 2015; 4:e002099.
Article
19. Payne GH, Fang J, Fogle CC, Oser CS, Wigand DA, Theisen V, et al. Stroke awareness: surveillance, educational campaigns, and public health practice. J Public Health Manag Pract. 2010; 16:345–358.
20. Froehler MT, Saver JL, Zaidat OO, Jahan R, Aziz-Sultan MA, Klucznik RP, et al. Interhospital transfer before thrombectomy is associated with delayed treatment and worse outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke). Circulation. 2017; 136:2311–2321.
21. Organek N, Milano N, Donohue M, Sundararajan S, Strbian D, Katzan IL. Significant period between presentation and diagnosis in basilar artery occlusion: five cases and the lessons learned. Stroke. 2015; 46:e79–e81.
Article
22. Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, et al. 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2018; 49:e46–e110.
Article
23. Lima FO, Silva GS, Furie KL, Frankel MR, Lev MH, Camargo ÉC, et al. Field assessment stroke triage for emergency destination: a simple and accurate prehospital scale to detect large vessel occlusion strokes. Stroke. 2016; 47:1997–2002.
Article
24. Ehntholt MS, Parasram M, Mir SA, Lerario MP. Mobile stroke units: bringing treatment to the patient. Curr Treat Options Neurol. 2020; 22:5.
Article
25. Amorim E, Shih MM, Koehler SA, Massaro LL, Zaidi SF, Jumaa MA, et al. Impact of telemedicine implementation in thrombolytic use for acute ischemic stroke: the University of Pittsburgh Medical Center telestroke network experience. J Stroke Cerebrovasc Dis. 2013; 22:527–531.
Article
26. Mayer SA, Viarasilpa T, Panyavachiraporn N, Brady M, Scozzari D, Van Harn M, et al. CTA-for-All: impact of emergency computed tomographic angiography for all patients with stroke presenting within 24 hours of onset. Stroke. 2020; 51:331–334.
Article
27. Sheth SA, Lopez-Rivera V, Barman A, Grotta JC, Yoo AJ, Lee S, et al. Machine learning-enabled automated determination of acute ischemic core from computed tomography angiography. Stroke. 2019; 50:3093–3100.
Article
28. Sarraj A, Savitz S, Pujara D, Kamal H, Carroll K, Shaker F, et al. Endovascular thrombectomy for acute ischemic strokes: current US access paradigms and optimization methodology. Stroke. 2020; 51:1207–1217.
Article
29. Aldstadt J, Waqas M, Yasumiishi M, Mokin M, Tutino VM, Rai HH, et al. Mapping access to endovascular stroke care in the USA and implications for transport models. J Neurointerv Surg. 2022; 14:neurintsurg-2020-016942.
30. Kamel H, Parikh NS, Chatterjee A, Kim LK, Saver JL, Schwamm LH, et al. Access to mechanical thrombectomy for ischemic stroke in the United States. Stroke. 2021; 52:2554–2561.
Article
31. Kim BM, Baek JH, Heo JH, Kim DJ, Nam HS, Kim YD. Effect of cumulative case volume on procedural and clinical outcomes in endovascular thrombectomy. Stroke. 2019; 50:1178–1183.
Article
32. Lavine SD, Cockroft K, Hoh B, Bambakidis N, Khalessi AA, Woo H, et al. Training guidelines for endovascular ischemic stroke intervention: an international multi-society consensus document. AJNR Am J Neuroradiol. 2016; 37:E31–E34.
33. Jauch EC, Schwamm LH, Panagos PD, Barbazzeni J, Dickson R, Dunne R, et al. Recommendations for regional stroke destination plans in rural, suburban, and urban communities from the Prehospital Stroke System of Care Consensus Conference: a consensus statement from the American Academy of Neurology, American Heart Association/American Stroke Association, American Society of Neuroradiology, National Association of EMS Physicians, National Association of State EMS Officials, Society of NeuroInterventional Surgery, and Society of Vascular and Interventional Neurology: endorsed by the Neurocritical Care Society. Stroke. 2021; 52:e133–e152.
Article
34. Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, et al. Accuracy of prediction instruments for diagnosing large vessel occlusion in individuals with suspected stroke: a systematic review for the 2018 guidelines for the early management of patients with acute ischemic stroke. Stroke. 2018; 49:e111–e122.
Article
35. Southerland AM, Johnston KC, Molina CA, Selim MH, Kamal N, Goyal M. Suspected large vessel occlusion: should emergency medical services transport to the nearest primary stroke center or bypass to a comprehensive stroke center with endovascular capabilities? Stroke. 2016; 47:1965–1967.
36. Zibulewsky J. The Emergency Medical Treatment and Active Labor Act (EMTALA): what it is and what it means for physicians. Proc (Bayl Univ Med Cent). 2001; 14:339–346.
Article
37. Waters H. Health financing for poor people: resource mobilization and risk sharing. Bull World Health Organ. 2005; 83:236.
38. Brinjikji W, Rabinstein AA, McDonald JS, Cloft HJ. Socioeconomic disparities in the utilization of mechanical thrombectomy for acute ischemic stroke in US hospitals. AJNR Am J Neuroradiol. 2014; 35:553–556.
Article
39. Centers for Disease Control and Prevention (CDC). Prevalence of stroke: United States, 2006-2010. MMWR Morb Mortal Wkly Rep. 2012; 61:379–382.
40. Attenello FJ, Adamczyk P, Wen G, He S, Zhang K, Russin JJ, et al. Racial and socioeconomic disparities in access to mechanical revascularization procedures for acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014; 23:327–334.
Article
41. Bouslama M, Rebello LC, Haussen DC, Grossberg JA, Anderson AM, Belagaje SR, et al. Endovascular therapy and ethnic disparities in stroke outcomes. Interv Neurol. 2018; 7:389–398.
Article
42. Vaughan Sarrazin M, Limaye K, Samaniego EA, Al Kasab S, Sheharyar A, Dandapat S, et al. Disparities in inter-hospital helicopter transportation for hispanics by geographic region: a threat to fairness in the era of thrombectomy. J Stroke Cerebrovasc Dis. 2019; 28:550–556.
Article
43. Malhotra A, Boltyenkov A, Wu X, Matouk CC, Forman HP, Gandhi D, et al. Endovascular contact aspiration versus stent retriever for revascularization in patients with acute ischemic stroke and large vessel occlusion: a cost-minimization analysis. World Neurosurg. 2020; 139:e23–e31.
Article
44. Guzauskas GF, Boudreau DM, Villa KF, Levine SR, Veenstra DL. The cost-effectiveness of primary stroke centers for acute stroke care. Stroke. 2012; 43:1617–1623.
45. Walsh KB. Non-invasive sensor technology for prehospital stroke diagnosis: current status and future directions. Int J Stroke. 2019; 14:592–602.
Article
46. Olive-Gadea M, Crespo C, Granes C, Hernandez-Perez M, Pérez de la Ossa N, Laredo C, et al. Deep learning based software to identify large vessel occlusion on noncontrast computed tomography. Stroke. 2020; 51:3133–3137.
Article
47. Al Kasab S, Almallouhi E, Grant C, Hewitt D, Hewitt J, Baki M, et al. Telestroke consultation in the emergency medical services unit: a novel approach to improve thrombolysis times. J Stroke Cerebrovasc Dis. 2021; 30:105710.
Article
48. Bar M, Kral J, Jonszta T, Marcian V, Kuliha M, Mikulik R. Interrater variability for CT angiography evaluation between neurologists and neuroradiologist in acute stroke patients. Br J Radiol. 2017; 90:20160670.
Article
49. Grotta JC, Lyden P, Brott T. Rethinking training and distribution of vascular neurology interventionists in the era of thrombectomy. Stroke. 2017; 48:2313–2317.
Article
50. Rincon F, Vibbert M, Childs V, Fry R, Caliguri D, Urtecho J, et al. Implementation of a model of robotic tele-presence (RTP) in the neuro-ICU: effect on critical care nursing team satisfaction. Neurocrit Care. 2012; 17:97–101.
Article
51. Ramsay AI, Morris S, Hoffman A, Hunter RM, Boaden R, McKevitt C, et al. Effects of centralizing acute stroke services on stroke care provision in two large metropolitan areas in England. Stroke. 2015; 46:2244–2251.
Article
52. Koh HK, Blakey CR, Roper AY. Healthy people 2020: a report card on the health of the nation. JAMA. 2014; 311:2475–2476.
Article
Full Text Links
  • JOS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr