J Mov Disord.
2022 Jan;15(1):1-14. 10.14802/jmd.21078.
Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
- Affiliations
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- 1Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
- 2Hallym Neurological Institute, Hallym University College of Medicine, Anyang, Korea
- 3Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
- KMID: 2525083
- DOI: http://doi.org/10.14802/jmd.21078
Abstract
- Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis of PD. Thus, achieving a better understanding of the interaction between inflammation and synucleinopathy in relation to the PD process will facilitate the development of promising disease-modifying therapies. In this review, the evidence of inflammation in PD is discussed, and human, animal, and laboratory studies relevant to the relationship between inflammation and αSyn are explored as well as new therapeutic targets associated with this relationship.
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