Kidney Res Clin Pract.  2021 Sep;40(3):411-418. 10.23876/j.krcp.20.220.

Hyperuricemia is a risk factor for the progression to end-stage renal disease in minimal change disease

• Song SH
• Oh TR
• Choi HS
• Kim CS
• Ryu DR
• Kim SG
• Park SH
• Ma SK
• Kim SW
• Bae EH
• on behalf of The Korean GlomeruloNEphritis sTudy Group (KoGNET)

• KMID: 2524387
• DOI: http://doi.org/10.23876/j.krcp.20.220

Abstract

Background
Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome worldwide. Hyperuricemia increases the end-stage renal disease (ESRD) risk in glomerulonephritis. In this study, we aimed to determine the effect of high serum uric acid levels on the progression to ESRD in MCD.
Methods
A total of 800 patients diagnosed with MCD by kidney biopsy were retrospectively analyzed. We determined the relationship of hyperuricemia with the progression to ESRD in MCD using the Cox proportional hazard model and Kaplan-Meier survival analysis. The primary outcome was defined as the initiation of dialysis or kidney transplantation.
Results
A total of 42 patients (5.3%) progressed to ESRD during the follow-up period. In the restricted cubic spline curve, serum uric acid levels exhibited a positive correlation with ESRD progression in patients with MCD. In the fully adjusted model, the risk of MCD progression increased by 29% for every 1 mg/dL increase in the baseline serum uric acid level (hazard ratio [HR], 1.29; 95% confidence interval [CI], 1.09–1.54; p = 0.004). Falling into the high uric acid group (serum uric acid level > 7 mg/dL in men and > 6 mg/dL in women) was also a risk factor for progression of MCD to ESRD (HR, 3.40; 95% CI, 1.59–7.31; p < 0.001).
Conclusion
Our study shows that hyperuricemia is an independent risk factor for the progression to ESRD in patients with MCD.

Keyword

Chronic kidney disease; End-stage renal disease; Hyperuricemia; Minimal change disease