Korean J Vet Res.
2021 Dec;61(4):e34. 10.14405/kjvr.2021.61.e34.
A clear cell hepatocellular carcinoma in an obese dog with hyperlipidemia: a case report
- Affiliations
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- 1Laboratory of Clinical Pathology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- 2BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- 3Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- 4Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
- KMID: 2524364
- DOI: http://doi.org/10.14405/kjvr.2021.61.e34
Abstract
- An 11-year-old obese dog was referred for a liver mass. Cytologic examination revealed vacuolated hepatocytes with mild pleomorphism. A partial liver lobectomy was performed. On histopathologic examination, the mass was diagnosed as hepatocellular carcinoma composed of hepatocytes with clear vacuoles. These findings were consistent with clear cell hepatocellular carcinoma (CCHCC). The CCHCC is a rare subtype of hepatocellular carcinoma in dogs, and clinical features are poorly defined. This is the first report on the cytological, histological and clinical aspects of CCHCC, suggesting that obesity and hyperlipidemia are potential risk factors for CCHCC in dogs.
