J Cancer Prev.
2021 Dec;26(4):237-243. 10.15430/JCP.2021.26.4.237.
Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression
- Affiliations
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- 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
- 2Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, Korea
- 3Research Institute of Human Ecology, Seoul National University, Seoul, Korea
- 4Department of Food and Nutrition, Sookmyung Women’s University, Seoul, Korea
- 5Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea
- KMID: 2524117
- DOI: http://doi.org/10.15430/JCP.2021.26.4.237
Abstract
- Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs and various catabolic products act as signalling molecules, which activate mechanisms ranging from protein synthesis to insulin secretion. Recently, BCAA metabolism has been suggested to contribute to cancer progression. Of particular interest is the modulation of the mTOR activity by BCAAs. There are likely multiple pathways involved in BCAA metabolism implicated in carcinogenesis. Understanding the mechanism(s) underlying altered BCAAs metabolism will significantly advance the current understanding of nutrient involvement in carcinogenesis and direct future studies to unravel the significance of BCCA metabolites in tumor development and progression.
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