Nat Prod Sci.  2021 Dec;27(4):274-279. 10.20307/nps.2021.27.4.274.

The Extract of Couroupita guianensis Aubl. Ameliorates Benign Prostatic Hyperplasia In Vitro and In Vivo

  • 1Department of Plant & Biomaterials Science, Gyeongsang National University, Jinju 52725, Republic of Korea
  • 2Gyeongnam Department of Environment & Toxicology, Korea Institute of Toxicology, 17 Jegok-gil, Munsan-eup 52834, Republic of Korea
  • 3Institute of Traditional Medicine, Ministry of Health, Vientiane 0103. Lao PDR
  • 4Ethnobotanical Database of Bangladesh, Tejgaon Dhaka 1208, Bangladesh
  • 5International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea


The therapeutic effects of the leaves of Couroupita guianensis, a large tropical tree in the family of Lecythidaceae improving testosterone-induced Benign Prostatic Hyperplasia (BPH) were tested In Vitro and In Vivo. In BPH rats induced by castration and testosterone treatment, the prostate index was improved in groups administered with the extracts of C. guianensis extracted with 50%-, 100%-ethanol or boiling water, which was comparable with positive control, finasteride. The extract C. guianensis leaves showed significant inhibition on the expressions of type 2 5-alpha reductase (5αR) in RWPE-1 human prostatic epithelial cells, and effectively attenuated the expressions of androgen receptor, type 2 5αR and proliferating cell nuclear antigen in LNCap human prostatic adenocarcinoma cells. The leaves of C. guianensis that exerted evident suppression on BPHrelated biomarkers In Vitro and improvement of prostate index In Vivo has a potential therapeutic use for the treatment of BPH.


Couroupita guianensis; benign prostatic hyperplasia; RWPE-1; LNCap; testosterone; in vivo
Full Text Links
  • NPS
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: