Blood Res.  2021 Dec;56(4):339-342. 10.5045/br.2021.2021093.

Therapy-related acute myeloid leukemia in a patient with B-cell acute lymphoblastic leukemia

Affiliations
  • 1Laboratory Oncology Unit, Dr Brairch, All India Institute of Medical Sciences, New Delhi, India
  • 2Department of Hematopathology, Medanta–The Medicity Hospital, Gurgaon, India
  • 3Department of Medical Oncology & Hematology, Medanta–The Medicity Hospital, Gurgaon, India


Figure

  • Fig. 1 Bone marrow aspirate showed lymphoblasts with scanty agranular cytoplasm (A). Bone marrow biopsy (Haematoxylin and Eosin stain, ×400) with IHC showed positivity for CD10 and PAX5 and negativity for CD33 (B).

  • Fig. 2 Bone marrow aspirate showed myeloblasts that were larger in size and had moderate granular cytoplasm (A). Bone marrow biopsy (Haematoxylin and Eosin stain, ×400) with IHC showed positivity for CD33 and negativity for CD10 and PAX5 (B).

  • Fig. 3 Karyogram showed 46,XX, -4, +8, der(17) t(15;17)(q24;q23), del(17)(p13), der(20) t(10;20) (q11.2; q13.3), +der(11)t(5;11)(q31;q13), using GTG staining and banding method, ×100 oil immersion, and Carl Zeiss Axioscope Z2, and was processed using IKAROS software (A). Interphase nuclei and metaphase showed monoallelic deletion of TP53 gene localized on 17p13.1 by FISH using LSI 17p13.1(TP53/CEN17) deletion probe [TP53-red, CEN17-green], Zytovysion, Germany (B).


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