Soonchunhyang Med Sci.  2021 Dec;27(2):71-74. 10.15746/sms.21.017.

Association of Body Mass Index and Waist Circumference with Prostate-Specific Antigen

• Lee J
• Shin HS
• Cho YJ
• Oh JE

• KMID: 2524013
• DOI: http://doi.org/10.15746/sms.21.017

Abstract

Objective
Prostate-specific antigen (PSA) is widely used as a screening tool of prostate cancer, although there has been a controversy about efficacy. In Korea, rapid growth of obesity prevalence in adult men is a one of the biggest health problems. The objective of this study was to evaluate the potential association between body mass index (BMI), waist circumference (WC) and PSA.
Methods
We calculated BMI and WC of a total of 25,603 males who visited the Soonchunhyang University Cheonan Hospital Health Promotion Center from January 2016 to December 2020. This was categorized as follows: BMI < 23 kg/m² (normal), 23 kg/m² ≤ BMI < 25 kg/m² (overweight), BMI ≥ 25 kg/m² (obesity) and WC < 90 cm (normal), WC ≥ 90 cm (abdominal obesity). We analyzed the association between BMI, WC and PSA.
Results
The mean PSA value was 1.08 ng/mL, 1.03 ng/mL, and 0.97 ng/mL at normal, overweight, and obesity group, respectively. The mean PSA value was 1.04 ng/mL and 0.96 ng/mL at normal and abdominal obesity group. Thus, the mean PSA value decreased with an increase in BMI and WC category (P < 0.001). The correlation coefficient between BMI, WC and PSA was -0.055, -0.044 and they were statistically significant (P < 0.001).
Conclusion
We observed a significant negative correlation between BMI, WC and PSA value. Therefore, PSA value should be considered in relation to BMI and WC.

Keyword

Prostate-specific antigen; Obesity; Body mass index; Waist circumference