Korean J Urol Oncol.  2018 Dec;16(3):103-109. 10.22465/kjuo.2018.16.3.103.

Relationship of Prostate-Specific Antigen Level With Obesity Indices in Korean Middle-Aged Population

• Min SK
• Choi K
• Kim BH
• Cho IC

• KMID: 2438603
• DOI: http://doi.org/10.22465/kjuo.2018.16.3.103

Abstract

PURPOSE
We evaluated the relationship of prostate-specific antigen (PSA) and obesity indices (weight, body mass index [BMI] and waist circumference [WC]) in Korean middle-aged men.
MATERIALS AND METHODS
From February to September 2013, 1,900 police men under 60 years old who participated in a prostate health screening program were included this cross-sectional study. All subjects underwent clinical examinations including weight, height, BMI, WC, fasting blood sugar, lipid profiles, estimated glomerular filtration rate (GFR), and PSA. Total prostate volume (TPV) was assessed clinically. Spearman correlation and multiple linear regression tests were performed to evaluate the obesity indices and PSA relationships.
RESULTS
The mean age was 52.0±4.7 years, and the mean PSA was 0.97±0.99 ng/mL. The PSA showed a significant positive correlation with the age (r=0.108, p < 0.01), TPV (r=0.349, p < 0.01), height (r=−0.052, p < 0.05), weight (r=0.186, p < 0.05), low-density lipoprotein cholesterol (r=0.056, p < 0.05), and GFR (r=−0.096, p < 0.01). All obesity indices including weight, BMI, and WC showed negative correlations with PSA (beta=−0.013, p < 0.001; beta=−0.039, p < 0.001; and beta=−0.010, p=0.005; respectively) in age and TPV-adjusted model.
CONCLUSIONS
Common obesity indices (weight, BMI, and WC) were associated with lower PSA in Korean middle-aged population. Thus, an individual's degree of obesity should be considered when PSA is checked in the first prostate cancer screening of life.

Keyword

Prostate-specific antigen; Middle-age; Obesity; Prostate cancer; Screening

MeSH Terms

Blood Glucose
Body Mass Index
Cholesterol
Cross-Sectional Studies
Fasting
Glomerular Filtration Rate
Humans
Linear Models
Lipoproteins
Male
Mass Screening
Obesity*
Police
Prostate
Prostate-Specific Antigen*
Prostatic Neoplasms
Waist Circumference
Blood Glucose
Cholesterol
Lipoproteins
Prostate-Specific Antigen