Immune Netw.
2021 Dec;21(6):e38. 10.4110/in.2021.21.e38.
SARS-CoV-2 Omicron Mutation Is Faster than the Chase: Multiple Mutations on Spike/ACE2 Interaction Residues
- Kim S
1,2 - Nguyen TT1,2
- Taitt AS1
- Jhun H3
- Park HY4
- Kim SH5
- Kim YG6
- Song EY7
- Lee Y8
- Yum H9
- Shin KC10
- Choi YK2
- Song CS2
- Yeom SC11
- Kim B12
- Netea M13
- Kim S1,2
- Affiliations
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- 1Laboratory of Cytokine Immunology, Department of Biomedical Science and Technology, Konkuk University, Seoul 05029, Korea
- 2College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
- 3Technical Assistance Center, Korea Food Research Institute, Wanju 55365, Korea
- 4Research Group of Functional Food Materials, Korea Food Research Institute, Wanju 55365, Korea
- 5Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
- 6Division of Rheumatology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea
- 7Department of Laboratory Medicine, Seoul National University Hospital, Seoul National University, Collage of Medicine, Seoul 03080, Korea
- 8Department of Medicine, Pusan Paik Hospital, Inje University College of Medicine, Busan 47392, Korea
- 9Pulmonary Science and Critical Care Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul 04551, Korea
- 10Center for Respiratory Disease, College of Medicine, Yeungnam University, Daegu 42415, Korea
- 11Graduate School of International Agricultural Technology, Seoul National University, Pyeongchang 25354, Korea
- 12Division of Vaccine Clinical Research Center for Vaccine Research, National Institute of Infectious Diseases, Cheongju 28160, Korea
- 13Department of Internal Medicine and Center for Infectious Diseases, Radboud University, Nijmegen 6500HB, Netherlands
- KMID: 2523799
- DOI: http://doi.org/10.4110/in.2021.21.e38
Abstract
- Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (B.1.1.529) Omicron variant originated from South Africa in the middle of November 2021. SARS-CoV-2 is also called coronavirus disease 2019 (COVID-19) since SARS-CoV-2 is the causative agent of COVID-19. Several studies already suggested that the SARS-CoV-2 Omicron variant would be the fastest transmissible variant compared to the previous 10 SARS-CoV-2 variants of concern, interest, and alert. Few clinical studies reported the high transmissibility of the Omicron variant but there is insufficient time to perform actual experiments to prove it, since the spread is so fast. We analyzed the SARS-CoV-2 Omicron variant, which revealed a very high rate of mutation at amino acid residues that interact with angiostatin-converting enzyme 2. The mutation rate of COVID-19 is faster than what we prepared vaccine program, antibody therapy, lockdown, and quarantine against COVID-19 so far. Thus, it is necessary to find better strategies to overcome the current crisis of COVID-19 pandemic.
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