Korean J Radiol.  2022 Jan;23(1):13-29. 10.3348/kjr.2021.0112.

Quantitative Evaluation of Hepatic Steatosis Using Advanced Imaging Techniques: Focusing on New Quantitative Ultrasound Techniques

Affiliations
  • 1Department of Radiology, Seoul National University Hospital, Seoul, Korea
  • 2Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
  • 3Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Korea
  • 4Ultrasound R&D 2 Group, Health & Medical Equipment Business, Samsung Electronics Co., Ltd., Seoul, Korea

Abstract

Nonalcoholic fatty liver disease, characterized by excessive accumulation of fat in the liver, is the most common chronic liver disease worldwide. The current standard for the detection of hepatic steatosis is liver biopsy; however, it is limited by invasiveness and sampling errors. Accordingly, MR spectroscopy and proton density fat fraction obtained with MRI have been accepted as non-invasive modalities for quantifying hepatic steatosis. Recently, various quantitative ultrasonography techniques have been developed and validated for the quantification of hepatic steatosis. These techniques measure various acoustic parameters, including attenuation coefficient, backscatter coefficient and speckle statistics, speed of sound, and shear wave elastography metrics. In this article, we introduce several representative quantitative ultrasonography techniques and their diagnostic value for the detection of hepatic steatosis.

Keyword

Liver; Liver steatosis; Quantitative evaluation; Ultrasound imaging; Quantitative ultrasound
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