Tissue Eng Regen Med.  2021 Dec;18(6):917-930. 10.1007/s13770-021-00356-x.

Research Models of the Nanoparticle-Mediated Drug Delivery across the Blood–Brain Barrier

• Li QY
• Lee JH
• Kim HW
• Jin GZ

• KMID: 2522567
• DOI: http://doi.org/10.1007/s13770-021-00356-x

Abstract

Brain diseases and damages come in many forms such as neurodegenerative diseases, tumors, and stroke. Millions of people currently suffer from neurological diseases worldwide. While Challenges of current diagnosis and treatment for neurological diseases are the drug delivery to the central nervous system. The Blood–Brain Barrier (BBB) limits the drug from reaching the targeted site thus showing poor effects. Nanoparticles that have advantage of the assembly at the nanoscale of available biomaterials can provide a delivery platform with potential to raising brain levels of either imaging therapeutic drugs or imaging. Therefore, successful modeling of the BBB is another crucial factor for the development of nanodrugs. In this review, we analyze the in vitro and in vivo findings achieved in various models, and outlook future development of nanodrugs for the successful treatment of brain diseases and damages.

Keyword

Neurological diseases; Nanoparticles; In vitro models; In vivo models; Blood brain barrier