Perinatology.  2021 Mar;32(1):12-17. 10.14734/PN.2021.32.1.12.

Iatrogenic Prelabor Premature Rupture of Membrane and Preterm Birth: an Experimental Mouse Study

• Wang EJ
• Kim HY
• Cho GJ
• Hong SC
• Oh MJ
• Kim HJ
• Ahn KH

• KMID: 2522507
• DOI: http://doi.org/10.14734/PN.2021.32.1.12

Abstract

Objective
We aimed to investigate whether mouse mothers born prematurely give birth to preterm pups.
Methods
Sexually mature female C57BL/6 mice were used. To create the pPROM model, the fetal membranes of the right uterus were pierced using sterile 21- or 26-gauge needles on gestational day 15.5.
Results
The mean gestational duration of the first-generation pPROM model was 17.5 days. The mean gestational duration for the second-generation female mice born prematurely from the pPROM model was 19.8 days. The gestational duration between the first and second generations was significantly different (P<0.01). The average pup weight was greater in the third-generation mice than in the second-generation mice.
Conclusion
Mice born to pPROM model mice did not give birth to preterm pups. It appears that mother born prematurely through iatrogenic pPROM does not have preterm birth.

Keyword

Cervix; Iatrogenic prelabor premature rupture of membrane; Offspring; Prelabor premature rupture of membrane; Preterm birth