Korean J Radiol.
2021 Nov;22(11):1858-1874. 10.3348/kjr.2020.1450.
Pre- and Post-Treatment Imaging of Primary Central Nervous System Tumors in the Molecular and Genetic Era
- Affiliations
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- 1Department of Radiology, Severance Hospital, Research Institute of Radiological Science and Center for Clinical Image Data Science, Yonsei University College of Medicine, Seoul, Korea
- 2Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
- KMID: 2521761
- DOI: http://doi.org/10.3348/kjr.2020.1450
Abstract
- Recent advances in the molecular and genetic characterization of central nervous system (CNS) tumors have ushered in a new era of tumor classification, diagnosis, and prognostic assessment. In this emerging and rapidly evolving molecular genetic era, imaging plays a critical role in the preoperative diagnosis and surgical planning, molecular marker prediction, targeted treatment planning, and post-therapy assessment of CNS tumors. This review provides an overview of the current imaging methods relevant to the molecular genetic classification of CNS tumors. Specifically, we focused on 1) the correlates between imaging features and specific molecular genetic markers and 2) the post-therapy imaging used for therapeutic assessment.
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