Yonsei Med J.  2021 Nov;62(11):1062-1068. 10.3349/ymj.2021.62.11.1062.

Developing a Dementia Platform Databank Using Multiple Existing Cohorts

Affiliations
  • 1Department of Digital Health, SAIHST, Sungkyunkwan University, Seoul, Korea
  • 2Center for Clinical Epidemiology, Samsung Medical Center, Seoul, Korea
  • 3Neuroscience Center, Samsung Medical Center, Seoul, Korea
  • 4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 5Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea
  • 6Center for Research Resource Standardization, Samsung Medical Center, Seoul, Korea
  • 7Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea
  • 8Department of Neurology, Inha University School of Medicine, Incheon, Korea

Abstract

This study was conducted as a pilot project to evaluate the feasibility of building an integrate dementia platform converging preexisting dementia cohorts from several variable levels. The following four cohorts were used to develop this pilot platform: 1) Clinical Research Center for Dementia of South Korea (CREDOS), 2) Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s disease (K-BASE), 3) Environmental Pollution-induced Neurological Effects (EPINEF) study, and 4) a prospective registry in Dementia Platform Korea project (DPKR). A total of 29916 patients were included in the platform with 348 integrated variables. Among participants, 13.9%, 31.5%, and 44.2% of patients had normal cognition, mild cognitive impairment, and dementia, respectively. The mean age was 72.4 years. Females accounted for 65.7% of all patients. Those with college or higher education and those without problems in reading or writing accounted for 12.3% and 46.8%, respectively. Marital status, cohabitation, family history of Parkinson’s disease, smoking and drinking status, physical activity, sleep status, and nutrition status had rates of missing information of 50% or more. Although individual cohorts were of the same domain and of high quality, we found there were several barriers to integrating individual cohorts, including variability in study variables and measurements. Although many researchers are trying to combine pre-existing cohorts, the process of integrating past data has not been easy. Therefore, it is necessary to establish a protocol with considerations for data integration at the cohort establishment stage.

Keyword

Dementia; platform; cohort; database
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