Korean J Otorhinolaryngol-Head Neck Surg.  2021 Sep;64(9):669-673. 10.3342/kjorl-hns.2020.00955.

A Case of Laryngeal Mucosa Associated Lymphoid Tissue Lymphoma Mimicking Laryngeal Amyloidosis

• Kim MW
• Kwak MY
• Choi JY
• Chang DS

• KMID: 2520389
• DOI: http://doi.org/10.3342/kjorl-hns.2020.00955

Abstract

Laryngeal amyloidosis is a rare disorder characterized by localized amyloid deposition and carries an excellent prognosis. On the other hand, mucosa associated lymphoid tissue (MALT) lymphoma is the most common type of marginal zone lymphoma. MALT lymphoma has a poorer prognosis compared to laryngeal amyloidosis due to more frequent local recurrence, distant metastasis and malignant changes. Despite the differences, as both are found in the form of benign mass and have slow progression, accurate diagnosis is necessary. This report deals with the case of a patient with voice change accompanied by a mass, in which the initial biopsy did not include enough specimen for an accurate diagnosis. However, in the second attempt, an adequate sample was obtained, hence the final diagnosis of laryngeal MALT lymphoma. Based on our recent experience and a review of related literature, we report a case of laryngeal MALT lymphoma mimicking laryngeal amyloidosis.

Keyword

Amyloidosis; Laryngeal cancer; Mucosa associated lymphoid tissue lymphoma