World J Mens Health.  2021 Oct;39(4):733-739. 10.5534/wjmh.200129.

Oral Testofen, L-Citrulline, Resveratrol, and Caffeine Supplement Drink Improves Sexual Function in Men with Phosphodiesterase 5 Inhibitors: Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study

• Shirai M
• Miyoshi Y
• Ogasa T
• Miyoshi M
• Ishikawa K
• Hiramatsu I
• Uesaka Y
• Nozaki T
• Koyama T
• Tsujimura A

• KMID: 2519914
• DOI: http://doi.org/10.5534/wjmh.200129

Abstract

Purpose
Sexuality is very important for men’s health. Currently, phosphodiesterase type 5 inhibitors (PDE5i) remain the firstline therapy for erectile dysfunction, and no other oral drugs or drinks are approved and used clinically to treat male libido or orgasm dysfunction. In reference to a pharmaceutical dosage document, growing health consciousness is said to have boosted yearly sales of supplement drinks to more than 170 billion yen (1.58 billion US dollars) in Japan. We have created a supplement drink comprised of testofen, L-citrulline, resveratrol, and caffeine. We hypothesized that our supplement drink would be effective for men with sexual dysfunction, and especially libido dysfunction.
Materials and Methods
In this study, men with sexual dysfunction received a placebo drink for 14 days or our supplement drink (testofen, 600 mg/d; L-citrulline, 800 mg/d; resveratrol, 300 mg/d; and caffeine, 40 mg/d) for another 14 days separated by a 7-day washout period. Patients continued on-demand use of PDE5i. The International Index of Erectile Function (IIEF) score and adverse events were assessed.
Results
Twenty patients aged 30–47 years old were enrolled in and concluded the study with no adverse events experienced. The IIEF domains of desire frequency, erection frequency, erection firmness, erection confidence, intercourse satisfaction, ejaculation frequency, orgasm frequency, and overall satisfaction were significantly improved with our supplement drink.
Conclusions
This is the first study to show that our supplement drink may not only be effective for erection but also for libido, orgasm, and ejaculation.

Keyword

Caffeine; Citrulline; Resveratrol; Sexual dysfunction; physiological; Trigonella