Korean J Med.  2021 Aug;96(4):328-336. 10.3904/kjm.2021.96.4.328.

Diagnosis and Management of Antibiotic Allergies

Affiliations
  • 1Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea

Abstract

Drug allergies encompass a spectrum of immune-mediated hypersensitivity reactions with various mechanisms and clinical presentations. β-lactam drugs are common causes of drug allergies. A detailed clinical history as well as skin and drug provocation tests, are essential to diagnose drug allergies. The key to successful treatment is avoidance or discontinuation of the offending drug, and replacing it with a safe alternative. Cross-reactivities among β-lactam antibiotics should be considered when choosing alternative medications. Proper management of β-lactam allergies is important at the individual and population levels, to reduce the likelihood of drug allergies and prevent antibiotic-related adverse outcomes.

Keyword

약물알레르기; 진단; 페니실린; 세파로스포린; Drug hypersensitivity; Diagnosis; Penicillins; Cephalosporins
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