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Diagnosis and Management of Antibiotic Allergies

Kim JH

Drug allergies encompass a spectrum of immune-mediated hypersensitivity reactions with various mechanisms and clinical presentations. β-lactam drugs are common causes of drug allergies. A detailed clinical history as well as...
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Prevalence and antimicrobial resistance of Klebsiella species isolated from clinically ill companion animals

Lee D, Oh JY, Sum S, Park HM

Background: Klebsiella spp. is an important conditional pathogen in humans and animals. However, due to the indiscriminate use of antibiotics, the incidence of antimicrobial resistance has increased. Objectives: The purpose of this...
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Comparison of antimicrobial resistances and clinical features in community-onset Escherichia coli and Klebsiella pneumoniae bacteremia

Sung HS, Lee JW, Bae S, Kwon KT

Background/Aims: The aim of this study was to compare antimicrobial resistance, clinical features, and outcomes of community-onset Escherichia coli (COEC) and Klebsiella pneumoniae (COKP) bacteremia. Methods: The medical records of patients...
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Beta-Lactam Allergy: Real Practice in a Regional Hospital

Kim H, Lee J, Kim S

Background/Aims: Beta-lactam (BL) antibiotics are widely prescribed for controlling bacterial infections and relevant culprits of adverse drug reactions (ADRs). BL allergy may vary according to prescription patterns within a given...
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Hypersensitivity Pneumonitis Caused by Cephalosporins With Identical R1 Side Chains

Lee SH, Kim MH, Lee K, Jo EJ, Park HK

Drug-induced hypersensitivity pneumonitis results from interactions between pharmacologic agents and the human immune system. We describe a 54-year-old man with hypersensitivity pneumonitis caused by cephalosporins with identical R1 side chains....
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A Comparison of Cefditoren Pivoxil 8-12 mg/kg/day and Cefditoren Pivoxil 16-20 mg/kg/day in Treatment of Children With Acute Presumed Bacterial Rhinosinusitis: A Prospective, Randomized, Investigator-Blinded, Parallel-Group Study

Poachanukoon O, Tangsathapornpong A, Tanuchit S

OBJECTIVES: Cefditoren pivoxil (CDT) has been used in the treatment of rhinosinusitis. However, little is known about the efficacy of this drug at low and high doses. This study was...
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Treatment of Neisseria gonorrhoeae in the Era of Multidrug Resistance

Chae JY, Oh MM

Neisseria gonorrhoeae (NG) is becoming increasingly less susceptible to the extended spectrum cephalosporin (ESC), which has been recommended for first-line treatment, and cases of treatment failure are being reported globally....
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Diagnosis and Management of Immediate Hypersensitivity Reactions to Cephalosporins

Kim MH, Lee JM

Cephalosporins can cause a range of hypersensitivity reactions, including IgE-mediated, immediate reactions. Cephalosporin allergy has been reported with use of a specific cephalosporin, as a cross-reaction between different cephalosporins or...
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Ceftiaxone-Induced Neurotoxicity: Case Report, Pharmacokinetic Considerations, and Literature Review

Kim KB, Kim SM, Park W, Kim JS, Kwon SK, Kim HY

Ceftriaxone is widely used in patients for the treatment of serious gram-negative infections. Ceftriaxone can induce some potential side effects, including neurotoxicity, however, nonconvulsive status epilepticus has rarely been reported....
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Nonconvulsive Status Epilepticus Caused by Cephalosporins in Patients with Renal Failure

Lee SH, Baek SH

  • KMID: 1811538
  • J Korean Epilepsy Soc.
  • 2012 Dec;16(2):37-42.
PURPOSE: To describe the clinical features of nonconvulsive status epilepticus (NCSE) associated with cephalosporins in patients with renal failure and to emphasize the importance of EEG in diagnosing NCSE in...
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Identifying Genetic Susceptibility to Sensitization to Cephalosporins in Health Care Workers

Nam YH, Kim JE, Kim SH, Jin HJ, Hwang EK, Shin YS, Ye YM, Park HS

Exposure to cephalosporins could cause occupational allergic diseases in health care workers (HCWs). We evaluated the prevalence of serum specific IgE and IgG antibodies to cephalosporin-human serum albumin (HSA) conjugate...
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Evaluation of Changed Antibiotics in Case of Positive Antibiotics Skin Test

  • KMID: 2090211
  • Korean J Asthma Allergy Clin Immunol.
  • 2011 Mar;31(1):48-54.
BACKGROUND: Antibiotics skin test (AST) is routinely performed to examine hypersensitivity in clinical practice. However, it is difficult to select antibiotics in case of positive AST because of poor validation...
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Prevalence and Risk Factors for Extended Spectrum Beta-Lactamase-Producing Uropathogens in Patients with Urinary Tract Infection

Lee DS, Lee CB, Lee SJ

  • KMID: 2314656
  • Korean J Urol.
  • 2010 Jul;51(7):492-497.
PURPOSE: The aim of this study was to determine the prevalence and risk factors of extended spectrum beta-lactamase (ESBL)-producing microorganisms in urinary tract infection. MATERIALS AND METHODS: total of 2,312 patients...
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IgE-Mediated Hypersensitivity Reactions to Cephalosporins

Kim BN, Cho YS

Cephalosporins are commonly prescribed either orally or parenterally for the treatment of bacterial infections because of wide safety margin compared with penicillins. Skin testing with a parent cephalosporin antibiotic has...
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A Case of Drug Eruption Induced by Various Cephalosporin Antibiotics

  • KMID: 2299568
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Sep;29(3):212-216.
The risk of allergic reactions to different cephalosporins in a patient with a history of allergy to 1 cephalosporin is not well known. Previous studies have suggested that the degree...
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Disposition kinetics and urinary excretion of cefpirome after intravenous injection in buffalo calves

Rajput N, Dumka VK, Sandhu HS

We investigated the disposition kinetics and urinary excretion of cefpirome in buffalo calves after a single intravenous administration of 10 mg/kg. Also, an appropriate dosage regimen was calculated. At 1...
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A Prospective Study for Comparing the Effects of Macrolide and Second-generation Cephalosporin on the Treatment of Pneumonia among Combat Policemen

Lee JI, Yang BY, Moon CK, Jeong JH, Kim JS, Lee JM, Ahn SJ, Jung JO, Park SJ, Kim YK, Kim SY, Kim YJ, Cho MK, Lee GJ, Lee GI

BACKGROUND: The study of pneumonia among young men living in a group is rare. prospective study was conducted to determine the etiology, and compare the effects of macrolide and second-generation...
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Prevalence and Mechanism of Third-Generation Cephalosporins-Resistant Escherichia coli and Klebsiella pneumoniae Strains Isolated from Clinical Specimen

Kim JM, Jeong SH, Lee SH, Kim JH, Kim BN, Kim JC

  • KMID: 2146996
  • Korean J Clin Microbiol.
  • 2002 Mar;5(1):6-14.
BACKGROUND: Among Gram-negative pathogens in Korea, the incidence of resistance to thirdgeneration cephalosporins is becoming an ever-increasing problem. This study was designed to determine the prevalence of third-generation cephalosporins-resistant Escherichia...
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Prevalence of Extended-spectrum beta-lactamase-producing Enterobacteriaceae and Evaluation of Methods for Detection

Kim BL, Jeong SH, Koo JY, Lee K, Chong Y, Jeong TJ, Hwang HY, Kim MH

  • KMID: 2147010
  • Korean J Clin Microbiol.
  • 1999 Mar;2(1):28-39.
BACKGROUND: Increased isolation of extended-spectrum beta-lactamase (ESBL)-producing Entero bacteriaceae resistant to third generation cephalosporins and aztreonam has been noted recently. This study was to determine the prevalence of resistance to...
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Cefuroxime Induced Immune Hemolytic Anemia

Lee SO, Kim JO, Yoon YO, Oh EJ, Kim Y, Park YJ, Cho SG, Wang YP, Kim BK

  • KMID: 2031029
  • Korean J Clin Pathol.
  • 1999 Oct;19(5):578-580.
Cephalosporins are commonly used antibiotics in treatment of clinical infection. They frequently cause a positive direct antiglobulin test, but rarely cause hemolysis. The authors report a case of immune hemolytic...
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