Anesth Pain Med.  2021 Jul;16(3):279-283. 10.17085/apm.21006.

Liver transplantation of a patient with extreme thrombocytopenia - A case report -

• Oh Y
• Yoo SY
• Choi GS
• Kim G

• KMID: 2519057
• DOI: http://doi.org/10.17085/apm.21006

Abstract

Background
Patients with chronic liver disease (CLD) planned for liver transplantation (LT) often show severe thrombocytopenia, but there is a lack of evidence in deciding the threshold for prophylactic platelet transfusion. Case: A 47-year-old women with acute liver failure was referred for LT. Despite daily transfusion of platelets, platelet counts remained under 10,000/µl. During LT, 2 units of single donor platelets (SDP) were transfused. Although platelet counts remained extremely low (3,000–4,000/µl) no diffuse oozing was observed and the blood loss was 860 ml. Postoperatively, there was no sign of active bleeding or oozing, and the patient received only 1 unit SDP transfusion.
Conclusions
CLD patients may have severe thrombocytopenia. However, primary hemostasis may not be significantly hindered due to the existence of rebalanced hemostasis. Prophylactic platelet transfusion in these patients should not be decided based on platelet counts only, but also take other coagulation tests and clinical signs into consideration.

Keyword

Liver transplantation; Platelet transfusion; Rebalanced hemostasis; Thrombocytopenia

Figure

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  Fig. 1. Perioperative platelet counts. SDP: single donor platelets, PC: platelet counts, POD: postoperative day.

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