J Korean Neurol Assoc.  2021 Aug;39(3):172-176. 10.17340/jkna.2021.3.9.

Patterns of Cerebrospinal Fluid Biomarkers and Amyloid Positron Emission Tomography in a Patient with Cerebral Amyloid Angiopathy-Related Inflammation

• Kim JY
• Jo S
• Park YJ
• Jung HJ
• Koo YS
• Lee JH

• KMID: 2518935
• DOI: http://doi.org/10.17340/jkna.2021.3.9

Abstract

Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a distinct subset of cerebral amyloid angiopathy characterized by the auto-inflammatory response to amyloid-laden small arteries of cerebral cortex and leptomeninges. Clinical features include cognitive-behavioral change, headache, focal neurologic deficits and seizure. Because anti-inflammatory treatments can rapidly relieve neurologic symptoms, early diagnosis is critical. Herein, we report a CAA-RI case with distinct laboratory findings of a decreased cerebrospinal fluid amyloid beta 1-42 level and relatively reduced florbetaben uptake in the focal inflammatory lesion during the acute phase of CAA-RI.

Keyword

Cerebral amyloid angiopathy-related inflammation; Cerebrospinal fluid amyloid beta; Amyloid positron emission tomography