Osong Public Health Res Perspect.  2014 Dec;5(6):378-382. 10.1016/j.phrp.2014.09.006.

Ebola Hemorrhagic Fever and the Current State of Vaccine Development

• Hong JE
• Hong KJ
• Choi WY
• Lee WJ
• Choi YH
• Jeong CH
• Cho Ki

• KMID: 2518167
• DOI: http://doi.org/10.1016/j.phrp.2014.09.006

Abstract

Current Ebola virus outbreak in West Africa already reached the total number of 1,323 including 729 deaths by July 31st. the fatality is around 55% in the southeastern area of Guinea, Sierra Leone, Liberia, and Nigeria. The number of patients with Ebola Hemorrhagic Fever (EHF) was continuously increasing even though the any effective therapeutics or vaccines has not been developed yet. The Ebola virus in Guinea showed 98% homology with Zaire Ebola Virus.Study of the pathogenesis of Ebola virus infection and assess of the various candidates of vaccine have been tried for a long time, especially in United States and some European countries. Even though the attenuated live vaccine and DNA vaccine containing Ebola viral genes were tested and showed efficacy in chimpanzees, those candidates still need clinical tests requiring much longer time than the preclinical development to be approved for the practical treatment.It can be expected to eradicate Ebola virus by a safe and efficient vaccine development similar to the case of smallpox virus which was extinguished from the world by the variola vaccine.

Keyword

Ebola virus; hemorrhagic fever; vaccine; outbreak