J Korean Acad Oral Health.  2021 Jun;45(2):87-91. 10.11149/jkaoh.2021.45.2.87.

Antibacterial effect of mouthwash containing CPC against dental caries caused bacteria

• Cho WH
• Cho JW
• Yoo HJ
• Shin KH
• Shin GH
• Jeon YM
• Lee JC

• KMID: 2517234
• DOI: http://doi.org/10.11149/jkaoh.2021.45.2.87

Abstract

Objectives
The purpose of this study was to evaluate and report the antibacterial efficacy in relation to oral disease-causing bacteria using a mouthwash containing 0.05% CPC in an in vitro test.
Methods
The sterilization test and susceptibility assay of mouthwash containing 0.05% CPC were investigated against Streptococcus mutans, Streptococcus sobrinus, and Lactobacillus acidophilus; Streptococcus sanguinis as oral bacteria related to dental caries; Enterococcus faecalis as apical periodontitis-related bacteria; and Actinomyces israelii, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Prevotella nigrescence, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Filifactor alocis as periodontal disease-related bacteria.
Results
In the sterilization test, most of the bacteria had more than 99.99% sterilizing power for all samples but compared to other bacteria, the sterilizing power of these samples was not successful for L. acidophilus and E. faecalis bacteria. When comparing the sterilization power between the samples, sample 3 (0.05% CPC+20% ethanol) was the strongest.
Conclusions
In the antimicrobial activity test, sample 3 inhibited growth at the lowest concentration overall.

Keyword

Cetylpyridinium chloride; Mouthwashes; Streptococcus mutans

Figure

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  Fig. 1 Susceptibility assay of S. mutans for mouthwash.

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  Fig. 2 Susceptibility assay of S. sobrinus for mouthwash.

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  Fig. 3 Susceptibility assay of S. sanguinis for mouthwash.

Reference

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