J Stroke.  2021 May;23(2):273-276. 10.5853/jos.2020.04588.

Anticoagulation versus Antiplatelet Therapy after Ischemic Stroke in the Patients with Atrial Fibrillation and Cerebral Microbleeds

• Choi KH
• Kim JH
• Lee C
• Kim JM
• Kang KW
• Kim JT
• Choi SM
• Park MS
• Cho KH

• KMID: 2516416
• DOI: http://doi.org/10.5853/jos.2020.04588

Figure

• 

  Figure 1. Incidence rates of stroke (A) and secondary outcomes (B-D) among patients receiving antithrombotic therapy. HR, hazards ratio; OAC, oral anticoagulant; AP, antiplatelet; CI, confidence interval.

• 

  Figure 2. The effects of anticoagulation versus that of antiplatelet therapy on stroke risk according to the burden (A, B) and location (C, D) of cerebral microbleed (CMB). AP, antiplatelet; HR, hazards ratio; OAC, oral anticoagulant; CI, confidence interval.

Reference

References

1. Wilson D, Ambler G, Shakeshaft C, Brown MM, Charidimou A, Al-Shahi Salman R, et al. Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study. Lancet Neurol. 2018; 17:539–547.

2. Choi KH, Kim JH, Lee C, Kim JM, Kang KW, Kim JT, et al. Microbleeds and outcome in patients with acute ischemic stroke and atrial fibrillation taking anticoagulants. Stroke. 2020; 51:3514–3522.

3. Selim M, Diener HC. Atrial fibrillation and microbleeds. Stroke. 2017; 48:2660–2664.

4. Xian Y, O’Brien EC, Liang L, Xu H, Schwamm LH, Fonarow GC, et al. Association of preceding antithrombotic treatment with acute ischemic stroke severity and in-hospital outcomes among patients with atrial fibrillation. JAMA. 2017; 317:1057–1067.

5. Shoamanesh A, Charidimou A, Sharma M, Hart RG. Should patients with ischemic stroke or transient ischemic attack with atrial fibrillation and microbleeds be anticoagulated? Stroke. 2017; 48:3408–3412.

6. Wilson D, Charidimou A, Ambler G, Fox ZV, Gregoire S, Rayson P, et al. Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: a meta-analysis. Neurology. 2016; 87:1501–1510.