J Vet Sci.  2021 May;22(3):e32. 10.4142/jvs.2021.22.e32.

Full-length ORF2 sequence-based genetic and phylogenetic characterization of Korean feline caliciviruses

Affiliations
  • 1Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
  • 2Department of Biotechnology, Inje University, Gimhae 50834, Korea

Abstract

Feline calicivirus (FCV) is a highly infectious pathogen in cats and widely distributed worldwide with high genetic variation. Full-length open reading frame 2 of 5 from recently isolated Korean FCV isolates were sequenced and compared with those of global isolates. The results of phylogenetic analysis supported dividing global FCV isolates into two genogroups (type I and II) and demonstrated the presence of genogroup II in Korea, indicating their geographic spread in East Asia. High sequence variations in region E of the FCV isolates emphasizes that a novel vaccine needs to be developed to induce protective immunity against various FCV strains.

Keyword

Feline calicivirus; phylogenetic analysis; genogroup; open reading frame 2
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