Int J Thyroidol.  2021 May;14(1):60-62. 10.11106/ijt.2021.14.1.60.

A Case of Papillary Thyroid Cancer Coexisting with Thyroid Tuberculosis

• Lim SJ
• Han MS
• Lee MK
• Park DH
• Kwon SY
• Oh KH

• KMID: 2516168
• DOI: http://doi.org/10.11106/ijt.2021.14.1.60

Abstract

Thyroid tuberculosis with papillary thyroid carcinoma is very rare. The current study shows the case of a 67-year-old female who was admitted to Ansan Hospital of Korea University, with her thyroid nodules showing signs of malignancy under ultrasonography. A histopathological examination proved the coexistence of papillary thyroid carcinoma (PTC) and thyroid tuberculosis (TB). A total thyroidectomy and excision of the enlarged left neck level II lymph node were performed. This report presents a rare case of coexistence of PTC and thyroid TB. Further investigation is needed to evaluate the possible role of PTC in thyroid mycobacterial infection.

Keyword

Tuberculosis; Carcinoma; Papillary; Thyroid

Figure

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  Fig. 1 Images and histological analysis of the thyroid and lymph node. (A) Ultrasonography showed hypoechoic nodule with microcalcifications in right thyroid and (B) enlarged lymph node of left neck level II. (C) The structures which composed of a fibrovascular core and lined by enlarged epithelial cells can be found in patients of PTC. (D) Histological characteristics of TB infection at thyroid and (E) lymph node showing epithelioid cells, lymphocytes and giant cells of Langerhans type, with necrotic caseation.

Reference

References

1. Sonkar AA, Rajamanickam S, Singh D. 2010; Papillary thyroid carcinoma: debate at rest. Indian J Cancer. 47(2):206–16. DOI: 10.4103/0019-509X.63025. PMID: 20448388.

2. Meng L, Hu S, Huang L, Xu C. 2014; Papillary thyroid cancer coexisting with thyroid tuberculosis: a case report. Oncol Lett. 7(5):1563–5. DOI: 10.3892/ol.2014.1901. PMID: 24765176. PMCID: PMC3997685.

3. Comert FB, Comert M, Kulah C, Tascilar O, Numanoglu G, Aydemir S. 2006; Colonic tuberculosis mimicking tumor perforation: a case report and review of the literature. Dig Dis Sci. 51(6):1039–42. DOI: 10.1007/s10620-006-8002-2. PMID: 16865564.

4. Bulbuloglu E, Ciralik H, Okur E, Ozdemir G, Ezberci F, Cetinkaya A. 2006; Tuberculosis of the thyroid gland: review of the literature. World J Surg. 30(2):149–55. DOI: 10.1007/s00268-005-0139-1. PMID: 16425087.

5. Ghosh A, Saha S, Bhattacharya B, Chattopadhay S. 2007; Primary tuberculosis of thyroid gland: a rare case report. Am J Otolaryngol. 28(4):267–70. DOI: 10.1016/j.amjoto.2006.09.005. PMID: 17606045.

6. Akbulut S, Sogutcu N, Arikanoglu Z, Bakir S, Ulku A, Yagmur Y. 2011; Thyroid tuberculosis in southeastern Turkey: is this the resurgence of a stubborn disease? World J Surg. 35(8):1847–52. DOI: 10.1007/s00268-011-1118-3. PMID: 21523497.

7. Kang M, Ojili V, Khandelwal N, Bhansali A. 2006; Tuberculous abscess of the thyroid gland: a report of two cases. J Clin Ultrasound. 34(5):254–7. DOI: 10.1002/jcu.20166. PMID: 16673371.

8. Goel MM, Budhwar P. 2008; Fine needle aspiration cytology and immunocytochemistry in tuberculous thyroiditis: a case report. Acta Cytol. 52(5):602–6. DOI: 10.1159/000325605. PMID: 18833825.

9. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2016; 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 26(1):1–133. DOI: 10.1089/thy.2015.0020. PMID: 26462967. PMCID: PMC4739132.

10. Raman L, Murray J, Banka R. 2014; Primary tuberculosis of the thyroid gland: an unexpected cause of thyrotoxicosis. BMJ Case Rep. 2014:DOI: 10.1136/bcr-2013-202792. PMID: 24577178. PMCID: PMC3939388.

11. Barnes P, Weatherstone R. 1979; Tuberculosis of the thyroid: two case reports. Br J Dis Chest. 73(2):187–91. DOI: 10.1016/0007-0971(79)90033-0. PMID: 119548.

12. Kataria SP, Tanwar P, Singh S, Kumar S. 2012; Primary tuberculosis of the thyroid gland: a case report. Asian Pac J Trop Biomed. 2(10):839–40. DOI: 10.1016/S2221-1691(12)60240-8. PMID: 23569858. PMCID: PMC3609221.