Korean J Dermatol.  2021 May;59(4):277-283.

Case-Control Study: The Effects of Synthetic Ceramide on Dandruff, Erythema, Sebum Secretion and Water Loss of Scalp

• Park HR
• Jeong KH
• Kim JE
• Kang H

Abstract

Background
Ceramide offers an important barrier function to the epidermis. It can reduce epidermal water loss and inhibit the production of dandruff. Ceramide is essential in protecting hair and can be used as a cosmetic ingredient to improve seborrheic dermatitis and uncomfortable symptoms.
Objective
We aimed to evaluate the efficacy of synthetic ceramide on dandruff, erythema, sebum secretion, and scalp water loss.
Methods
We enrolled 20 subjects. Ten were randomly assigned to a group using a synthetic ceramide containing shampoo and the other 10 were assigned to the control group. The subjects underwent evaluation of the scalp before the trial and after using the shampoo for 4 weeks. Scores were given for dandruff and scalp erythema. Sebum secretions were evaluated using a sebumeter and were checked at four different scalp sites. The water content of the scalp was measured using a corneometer at the same sites.
Results
After 4 weeks, 8 patients showed favorable outcomes in dandruff in the ceramide group compared to 4 patients in the control group. Four patients displayed favorable outcomes in erythema in the ceramide group compared to 3 patients in the control group. Sebum secretion increased in the ceramide group and decreased in the control group, but the difference was not statistically significant. The water content showed a tendency to increase in the ceramide group, whereas the water content significantly decreased in the control group.
Conclusion
These results indicate that synthetic ceramide is effective at improving dandruff, erythema, and reducing scalp water loss.

Keyword

Ceramides; Dandruff; Erythema; Sebum