J Korean Ophthalmol Soc.  2021 May;62(5):688-691. 10.3341/jkos.2021.62.5.688.

Squamous Cell Carcinoma in the Lacrimal Sac of Young Patient Who Had Conjunctival Squamous Papilloma

• Lee DW
• Park MH
• Cho YW
• Kim SJ
• Seo SW

• KMID: 2515952
• DOI: http://doi.org/10.3341/jkos.2021.62.5.688

Abstract

Purpose
To report a squamous cell carcinoma in the lacrimal sac of a young patient.
Case summary
A 30-year-old female patient who had a history of conjunctival squamous papilloma resected at 15 years of age complained of pain and a mass around the right lacrimal sac that had occurred 1 week prior. Antibiotic treatment for 10 days under suspicion of dacryocystitis did not relieve her symptoms. After being diagnosed with lacrimal sac obstruction after dacryocystography, a 1.7 × 1.7 cm round mass was found on orbit non-contrast computed tomography. Endonasal dacryocystorhinostomy and excisional biopsy were performed. Histopathological examination revealed the initial invasive squamous cell carcinoma. An additional resected tissue biopsy was performed later. The mass diagnosed as carcinoma was completely resected and it was confirmed that there were no malignant cells around the resected area.
Conclusions
Squamous cell carcinoma of the lacrimal sac is rare and is known to be less common in young patients. It is believed that this case should not exclude the possibility of malignant tumors of the lacrimal sac regardless of age. Given that squamous cell carcinoma of the lacrimal sac is associated with a high-risk of human papillomavirus, this disease should be considered if there is a history of papilloma.

Keyword

Nasolacrimal duct, Papilloma, Papillomavirus, Squamous cell carcinoma