Intest Res.  2021 Apr;19(2):206-216. 10.5217/ir.2019.09169.

Colitis and Crohn’s Foundation (India): a first nationwide inflammatory bowel disease registry

Affiliations
  • 1Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, India
  • 2Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, India
  • 3Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, India
  • 4Department of Community Medicine, Dayanand Medical College and Hospital, Ludhiana, India
  • 5Department of Gastroenterology, Govind Ballabh Pant Hospital, New Delhi, India
  • 6Department of Gastroenterology, Gauhati Medical College, Guwahati, India
  • 7P. D. Hinduja Hospital and Medical Research Centre, Mumbai, India
  • 8Department of Gastroenterology, Kasturba Medical College, Manipal, India
  • 9Citizens Centre for Digestive Disorders, Hyderabad, India
  • 10Lisie Institute of Gastroenterology, Kochi, India
  • 11Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  • 12Department of Gastroenterology, Sawai Man Singh Medical College, Jaipur, India
  • 13Department of Gastroenterology, King Edward Memorial Hospital, Mumbai, India
  • 14Purnachandra Gastroenterology Institute, Guntur, India

Abstract

Background/Aims
The national registry for inflammatory bowel disease (IBD) was designed to study epidemiology and prescribing pattern of treatment of IBD in India.
Methods
A multicenter, cross-sectional, prospective registry was established across four geographical zones of India. Adult patients with ulcerative colitis (UC) or Crohn’s disease (CD) were enrolled between January 2014 and December 2015. Information related to demographics; disease features; complications; and treatment history were collected and analyzed.
Results
A total of 3,863 patients (mean age, 36.7 ± 13.6 years; 3,232 UC [83.7%] and 631 CD [16.3%]) were enrolled. The majority of patients with UC (n = 1,870, 57.9%) were from north, CD was more common in south (n = 348, 55.5%). The UC:CD ratio was 5.1:1. There was a male predominance (male:female = 1.6:1). The commonest presentation of UC was moderately severe (n = 1,939, 60%) and E2 disease (n = 1,895, 58.6%). Patients with CD most commonly presented with ileocolonic (n = 229, 36.3%) inflammatory (n = 504, 79.9%) disease. Extraintestinal manifestations were recorded among 13% and 20% of patients in UC and CD respectively. Less than 1% patients from both cohorts developed colon cancer (n = 26, 0.7%). The commonly used drugs were 5-aminosalicylates (99%) in both UC and CD followed by azathioprine (34.4%). Biologics were used in only 1.5% of patients; more commonly for UC in north and CD in south.
Conclusions
The national IBD registry brings out diversities in the 4 geographical zones of India. This will help in aiding research on IBD and improving quality of patient care.

Keyword

Inflammatory bowel disease; National registry; Colitis, ulcerative; India; Crohn disease
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