J Korean Geriatr Psychiatry.  2021 Apr;25(1):1-7. 10.47825/jkgp.2021.25.1.1.

Predicting Mild Cognitive Impairment to Alzheimer’s Disease Transition: Role of Instrumental Activities of Daily Living

  • 1Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  • 2Department of Industrial Psychology, Kwangwoon University, Seoul, Korea


This study aimed to investigate the association with the functioning of instrumental-activities of daily living (I-ADL) and future development of Alzheimer’s disease (AD) in persons with mild cognitive impairment (MCI).
A total of 116 patients with MCI, aged 65 years to 91 years (male: 88, female: 91 at first visit), from a large hospital cen-ter in Korea, were identified. Those who developed at least two consecutive 1-year follow up were diagnosed according to the DSM-5 criteria.
When the same level of Mini Mental State Examination (MMSE) scores was given, it could be seen that the probability of AD transfer was predicted differently due to complex changes in I-ADL scores. Specifically, it was observed that with an MMSE score of approximately 23.9 points, as the I-ADL points increase, the odds of transfer also increase approximately 6.1% (I-ADL low: 8.5 points) to 23.5% (I-ADL high: 31.4), therefore odds of transfer are 17.4% higher than I-ADL low condition.
The study suggested that even though cognitive problems were not observed due to high MMSE scores, severe damage to I-ADL could lead to AD. Applications may be limited, but such cases may require careful monitoring at the site.


Instrumental activities of daily living; Mild cognitive impairment; Dementia
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