Allergy Asthma Respir Dis.  2021 Apr;9(2):84-92. 10.4168/aard.2021.9.2.84.

Incidence of adverse drug reaction among 6 iodinated contrast media

• Koh E
• Kim YJ
• Kang N
• Jin SR
• Lee JY
• Eo H
• Choi DC
• Lee BJ

• KMID: 2515255
• DOI: http://doi.org/10.4168/aard.2021.9.2.84

Abstract

Purpose
Contrast media is one of the most common cause of adverse drug reaction (ADR) in adult. However, there was little data reported about differences in ADR ratio and severity among iodinated contrast media (ICM).
Methods
Medical records of 627,049 patients who performed computed tomography scan using low-osmolar nonionic iodinated contrast media from January 2015 to December 2018 were retrospectively reviewed. A total of 6 ICMs including iomeprol, iohexol, iopromide, iobitridol, ioversol, and iopamidol were used in this period. The incidence of ADR was compared to their total usage and dosage between each contrast media.
Results
The incidence of ADR of iopromide (1.36%) and iomeprol (1.27%) was the highest when compared with the average incidence of 1% of 6 ICMs. Ioversol (0.67%), iohexol, and iobitridol (0.74%) had the lower incidence of ADR. The order of results adjusted by actual administered dosage, the use of premedication, and the prior exposure history of ICMs was similar. The fraction of moderate and severe ADR in overall ADR was slightly different, but not proportional to the incidence of ADR.
Conclusion
The incidence of ADR among 6 low-osmolar nonionic ICMs was significantly different when compared by the total number of usage and the total volume of dose. The incidence of ADR varied by nearly 2-fold depending on ICMs. Further study might need to explore the reason for the difference of incidence.

Keyword

Iodinated contrast media; Adverse drug reaction; Iodinated contrast media; Adverse drug reaction