J Adv Prosthodont.  2021 Apr;13(2):100-106. 10.4047/jap.2021.13.2.100.

Evaluation of antibacterial activity against Candida albicans according to the dosage of various denture cleansers

• Bae CH
• Lim YK
• Kook JK
• Son MK
• Heo YR

• KMID: 2515200
• DOI: http://doi.org/10.4047/jap.2021.13.2.100

Abstract

PURPOSE
The purpose of this study is to compare the antibacterial activity of currently purchasable denture cleansers against Candida albicans.
Materials and methods
This study used tablet-type denture cleansers, Polident^Ⓡ , Coolingdent^Ⓡ and Fittydent^Ⓡ , along with liquid denture cleansers, Hexamedine^Ⓡ , Listerine^Ⓡ and Apple vinegar^Ⓡ . The antibacterial activities of denture cleansers were evaluated based on the number of C. albicans and concentrations of the denture cleansers.
Results
In the 0.5 × 10⁶ cfu/㎖ culture medium, the C. albicans’ death rate of Polident^Ⓡ was significantly lower than those of Fittydent^Ⓡ , Hexamedine^Ⓡ , Listerine^Ⓡ , and Apple vinegar^Ⓡ (P <.05). In the 0.5 × 10⁷ cfu/, the C. albicans’ death rates of Polident^Ⓡ and Coolingdent^Ⓡ were significantly lower than those of Fittydent^Ⓡ , Hexamedine^Ⓡ , Listerine^Ⓡ and Apple vinegar^Ⓡ (P <.05). The C. albicans’ death rates of Polident^Ⓡ and Coolingdent^Ⓡ were significantly decreased at 0.02 g and 0.01 g. The C. albicans’ death rate of Fittydent^Ⓡ was significantly decreased at 0.005 g (P <.05). The C. albicans’ death rate of Hexamedine^Ⓡ was significantly decreased at 1/16 dilution. The C. albicans’ death rate of Listerine^Ⓡ was decreased at 1/8 dilution, and the antibacterial activity of Apple vinegar^Ⓡ was decreased at 1/4 dilution (P<.05).
Conclusion
As the number of C. albicans increased, the antibacterial activities of the denture cleansers decrease. In the tablet-type denture cleanser, all denture cleansers showed 100% C. albicans’ death rate when used at a dose of 1 tablet. One denture cleanser showed the same antibacterial effect with only 1/3 of a tablet. In the liquid type denture cleanser, the level of dilution required was different for each denture cleanser.

Keyword

Antibacterial activity; C. albicans; Liquid denture cleanser; Tablet type denture cleanser