J Liver Cancer.  2021 Mar;21(1):92-96. 10.17998/jlc.21.1.92.

A Case of Metastatic Melanoma in the Liver Mimicking Hepatocellular Carcinoma

  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea


The liver is one of the most common sites of metastasis. Although most metastatic liver cancers are hypovascular, some hypervascular metastases, such as those from melanoma, need to be differentiated from hepatocellular carcinoma (HCC) because they may show similar radiologic findings due to their hypervascularity. We encountered a case of multinodular liver masses with hyperenhancement during the arterial phase and washout during the portal venous and delayed phases, which were consistent with imaging hallmarks of HCC. The patient had a history of malignant melanoma and had undergone curative resection 11 years earlier. We performed a liver biopsy for pathologic confirmation, which revealed a metastatic melanoma of the liver. Metastatic liver cancer should be considered if a patient without chronic liver disease has a history of other primary malignancies, and caution should be exercised with hypervascular cancers that may mimic HCC.


Metastasis; Melanoma; Liver neoplasms; Carcinoma, Hepatocellular
Full Text Links
  • JLC
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2022 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr