J Korean Acad Pediatr Dent.
2020 May;47(2):120-127. 10.5933/JKAPD.2020.47.2.120.
Antimicrobial Effect of Photodynamic Therapy Using Plaque Disclosing Agent
- Affiliations
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- 1Department of Pediatric Dentistry, Oral Science Research Center, College of Dentistry, Gangneung-Wonju National University
- 2Department of Microbiology and Immunology, College of Dentistry, Gangneung-Wonju National University
- KMID: 2511414
- DOI: http://doi.org/10.5933/JKAPD.2020.47.2.120
Abstract
- The aim of this study was to evaluate the antimicrobial effect of photodynamic therapy (PDT) using plaque disclosing agent, 10 - 20 mM erythrosine, as a photosensitizer.
Multispecies cariogenic biofilms containing Streptococcus mutans , Lactobacillus casei and Candida albicans were formed on hydroxyapatite disc. 20 μM, 10 mM and 20 mM erythrosine were applied as a photosensitizer for 3 minutes, and then light-emitting diode (LED) irradiated for 24 seconds. Colony-forming unit (CFU) were measured and biofilms were observed using confocal laser scanning microscopy (CLSM). CFU were significantly decreased in the PDT groups using 10 - 20 mM erythrosine (10 mM, 20mM) and the results were also confirmed by CLSM.
This study confirms the high antimicrobial effect of photodynamic therapy using plaque disclosing agent as a photosensitizer.
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