Pediatr Emerg Med J.
2020 Dec;7(2):140-144. 10.22470/pemj.2020.00143.
A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants
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- 1Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
- KMID: 2511136
- DOI: http://doi.org/10.22470/pemj.2020.00143
Abstract
- Kawasaki disease (KD) is a common febrile disease in East Asia. Because KD with coronary artery aneurysm (CAA) may predispose to thrombosis, children with KD-associated CAA may need anticoagulation in addition to aspirin. In this report, we describe a 6-year-old girl with KD and CAA who was found to have unexpected warfarin-induced coagulopathy caused by CYP2C9 and VKORC1 genotype variants, which affect warfarin metabolism.
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