Ann Clin Neurophysiol.  2020 Oct;22(2):125-128. 10.14253/acn.2020.22.2.125.

Focal eosinophilic myositis presenting with leg pain and tenderness

• Shin JH
• Kim DS

• KMID: 2511090
• DOI: http://doi.org/10.14253/acn.2020.22.2.125

Abstract

Focal eosinophilic myositis (FEM) is the most limited form of eosinophilic myositis that commonly affects the muscles of the lower leg without systemic manifestations. We report a patient with FEM who was studied by magnetic resonance imaging and muscle biopsy with a review of the literature.

Keyword

Myositis; Eosinophils; Magnetic resonance imaging

Figure

• 

  Fig. 1. T2-weighted muscle magnetic resonance imaging at the right mid-calf level shows multifocal high signal intensities in the tibialis anterior, extensor digitorum longus, and gastrocnemius muscles (A, white arrows). Gadolinium-enhanced T1-weighted image shows an enhancement at the same area (B).

• 

  Fig. 2. Muscle biopsy from tibialis anterior muscle shows mononuclear cellular infiltrates in perimysial (A, white arrow) and perivascular (B, black arrow) spaces. Increased number of muscle fibers with internal nuclei was also observed (A). Black bar indicates 100 μm. (A) Hematoxylin and eosin stain (×200). (B) Modified Gomori-trichrome stain (×200).

Reference

1. Kaufman LD, Kephart GM, Seidman RJ, Buhner D, Qvarfordt I, Nässberger L, et al. The spectrum of eosinophilic myositis. Clinical and immunopathogenic studies of three patients, and review of the literature. Arthritis Rheum. 1993; 36:1014–1024.

2. Selva-O’Callaghan A, Trallero-Araguás E, Grau JM. Eosinophilic myositis: an updated review. Autoimmun Rev. 2014; 13:375–378.

3. Gotlib J. World Health Organization-defined eosinophilic disorders: 2017 update on diagnosis, risk stratification, and management. Am J Hematol. 2017; 92:1243–1259.

4. Trüeb RM, Pericin M, Winzeler B, Wüthrich B, Burge G. Eosinophilic myositis/perimyositis: frequency and spectrum of cutaneous manifestations. J Am Acad Dermatol. 1997; 37:385–391.

5. Kobayashi Y, Fujimoto T, Shiiki H, Kitaoka K, Murata K, Dohi K. Focal eosinophilic myositis. Clin Rheumatol. 2001; 20:369–371.

6. Matsuse D, Ikezoe K, Shigeto H, Murai H, Ohyagi Y, Kira J. Case of eosinophilic myositis in continuum from localized nodular myositis. Rinsho Shinkeigaku. 2008; 48:36–42.