Korean J Clin Pharm.  2020 Mar;30(1):44-50. 10.24304/kjcp.2020.30.1.44.

Evaluation of Information Consistency of Clinically Significant Drug Interactions in Tyrosine Kinase Inhibitors

Affiliations
  • 1College of Pharmacy, Gachon University, Yeonsu-gu, Incheon 21936, Republic of Korea
  • 2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 07061, Republic of Korea
  • 3College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea

Abstract

Background
Drug-drug interactions (DDIs) in patients using oral anticancer treatment are more common than in those using injectable anticancer agents. In addition, DDIs related to anticancer treatment are known to cause clinically significant outcomes, such as treatment failure and severe toxicity. To prevent these negative outcomes, significant DDIs are monitored and managed using the information provided in drug databases. We aimed to evaluate the consistency of information on clinically significant DDIs for tyrosine kinase inhibitors (TKIs) between representative drug databases.
Methods
We selected clinically significant DDIs involving medications that are co-prescribed with TKIs and met the following criteria: the severity level of DDIs was equal or greater than “D” in Lexicomp® or “major” in Micromedex® . We then analyzed the consistency of the severity classification and evidence level between the drug databases. Spearman’s correlation coefficient was used to identify the relationship between DDI information in the drug databases.
Results
In total, 627 DDI pairs were identified as clinically significant; information on these was provided by Lexicomp® and Micromedex® for 571 and 438 pairs, respectively, and both drug databases provided information on 382 DDI pairs. There was no correlation between the severity and evidence level of DDIs provided in the two databases; Spearman’s correlation coefficient for Lexicomp® and Micromedex® was -0.009 (p=0.861) and -0.064 (p=0.209), respectively.
Conclusion
To judge the significance of DDIs, healthcare providers should consider that the information on DDIs may be different between drug information databases; hence, clinical factors must be considered concurrently.

Keyword

Tyrosine kinase inhibitors; drug interactions; information consistency
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