J Obes Metab Syndr.
2020 Dec;29(4):248-259. 10.7570/jomes20120.
Leptin as a Key between Obesity and Cardiovascular Disease
- Affiliations
-
- 1Division of Cardiology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea
- 2Department of Cardiovascular Pharmacology, Mokpo National University, Mokpo, Korea
- 3Division of Endocrinology, Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Korea
- 4Department of Biochemistry-Molecular Biology, Eulji University School of Medicine, Daejeon, Korea
- KMID: 2510161
- DOI: http://doi.org/10.7570/jomes20120
Abstract
- Obesity increases the risk of cardiovascular disease through various influencing factors. Leptin, which is predominantly secreted by adipose tissue, regulates satiety homeostasis and energy balance, and influences cardiovascular functions directly and indirectly. Leptin appears to play a role in heart protection in leptin-deficient and leptin-receptor-deficient rodent model experiments. Hyperleptinemia or leptin resistance in human obesity influences the vascular endothelium, cardiovascular structure and functions, inflammation, and sympathetic activity, which may lead to cardiovascular disease. Leptin is involved in many processes, including signal transduction, vascular endothelial function, and cardiac structural remodeling. However, the dual (positive and negative) regulator effect of leptin and its receptor on cardiovascular disease has not been completely understood. The protective role of leptin signaling in cardiovascular disease could be a promising target for cardiovascular disease prevention in obese patients.
