Korean J Fam Pract.  2020 Dec;10(6):456-460. 10.21215/kjfp.2020.10.6.456.

Relationship between Serum Vitamin E Level and Serum High-Sensitivity C-Reactive Protein in Koreans: Based on National Health and Nutrition Survey

• Kim J
• Kim S

• KMID: 2509640
• DOI: http://doi.org/10.21215/kjfp.2020.10.6.456

Abstract

Background
Inflammation plays a major role in atherothrombosis, and measuring inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) may provide a novel method for identifying individuals at high risk of plaque rupture. Atherogenesis results from the oxidation of lipids in low-density lipoprotein (LDL). Vitamin E facilitates the reduction in LDL-oxidation, and increases the antioxidant defense system. Therefore, our study aimed to examine the relationship between vitamin E and hs-CRP levels in Korean adults.
Methods
We used data from the Seventh Korea National Health and Nutrition Examination Survey (2016–2018). The study population included healthy adults aged >20 years. We investigated age, blood pressure, glucose levels, total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, body mass index, serum vitamin E, and serum hs-CRP levels. We analyzed the relationship between serum vitamin E and serum hs-CRP levels using multiple regression tests.
Results
On statistical analysis, vitamin E levels showed a positive correlation with hs-CRP levels in the female group and the total of the unadjusted model. However, the R 2 value is low. After adjustment for factors that may affect hs-CRP, no significant correlation was observed between serum vitamin E and serum hs-CRP levels.
Conclusion
No significant correlation was observed between serum vitamin E and serum hs-CRP levels. Further research is needed on this topic.

Keyword

Vitamin E; High-Sensitivity C-Reactive Protein; Cardiovascular Disease; Antioxidant