Korean J Transplant.  2020 Dec;34(Supple 1):S37. 10.4285/ATW2020.OP-1244.

Kidney transplantation from deceased donors with bloodstream infection: a multicenter retrospective study

Affiliations
  • 1Department of Surgery, SMG-SNU Boramae Medical Center, Seoul, Korea
  • 2Department of Surgery, Severance Hospital, Seoul, Korea
  • 3Department of Surgery, Samsung Medical Center, Seoul, Korea
  • 4Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
  • 5Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
  • 6Department of Surgery, Seoul National University Hospital, Seoul, Korea

Abstract

Background
The use of organs from donors with infection is limited because of the possibility of transmission. Herein, we report our experience of transplantation from deceased donors with blood stream infection (BSI).
Methods
Retrospective study of patients undergoing kidney or pancreas transplantation at five tertiary centers in Korea from January 2009 and November 2019 was performed. We analyzed the outcomes of patients who received transplantation from deceased donors who had BSI before transplantation.
Results
During study period, 88 recipients received transplantation from 70 donors with BSI. The most common isolated pathogens from donors were Gram-positive bacteria (72.8%), followed by Gram-negative bacteria (22.1%), and Fungi (5.2%). Appropriate antibiotics were used in 47.1% of donors before transplantation and in 38.6% of recipients after transplantation. In the case of bacterial infection, transmission occurred only in one of 83 recipients (1.2%). A recipient from donor with carbapenem-resistant Acinetobacter baumannii developed urinary tract infection early after transplant. The infection resolved after 7 days of targeted antibiotic therapy. In the case of fungal infection, transmission of fungal infection occurred in three out of eight recipients (37.5%). One recipient had received 7 days of antifungal therapy for Candida species after transplant; however, persistent fungemia and infected endocarditis developed and required surgical treatment. The other two recipients did not receive antifungal therapy before symptom onset and subsequently died of donor-derived scedosporiosis.
Conclusions
Using organs from donors with bacteremia seems to be a safe option with low risk of transmission. Whether to use organs from donors with fungemia should be cautiously determined.

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