Clin Psychopharmacol Neurosci.
2020 Nov;18(4):599-606. 10.9758/cpn.2020.18.4.599.
Factors Associated with Doses of Mood Stabilizers in Real-world Outpatients with Bipolar Disorder
- Yasui-Furukori N
1,2 - Adachi N3
- Kubota Y3
- Azekawa T3
- Goto E3
- Edagawa K3
- Katsumoto E3
- Hongo S3
- Ueda H3
- Miki K3
- Kato M2,4
- Yoshimura R2,5
- Nakagawa A2,6
- Kikuchi T2,6
- Tsuboi T2,7
- Watanabe K2,7
- Shimoda K1
- Affiliations
-
- 1Department of Psychiatry, Dokkyo Medical University, School of Medicine, Tochigi, Japan
- 2The Japanese Society of Clinical Neuropsychopharmacology, Japan
- 3The Japanese Association of Neuro-Psychiatric Clinics, Tokyo, Japan
- 4Department of Neuropsychiatry, Kansai Medical University, Hirakata, Japan
- 5Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
- 6Department of Neuropsychiatry, Keio University School of Medicine, Minato, Japan
- 7Department of Neuropsychiatry, Kyorin University School of Medicine, Mitaka, Japan
- KMID: 2508984
- DOI: http://doi.org/10.9758/cpn.2020.18.4.599
Abstract
Objective
Several evidence-based practice guidelines have been developed to better treat bipolar disorder. However, the articles cited in these guidelines were based on clinical or basic studies with specific conditional settings and were not sufficiently based on real-world clinical practice. In particular, there was little information on the doses of mood stabilizers.
Methods
The MUlticenter treatment SUrvey on BIpolar disorder in Japanese psychiatric clinics (MUSUBI) is a study conducted to accumulate evidence on the real-world practical treatment of bipolar disorder. The questionnaire included patient characteristics such as comorbidities, mental status, treatment period, Global Assessment of Functioning (GAF) score, and details of pharmacological treatment.
Results
Most patients received mood stabilizers such as lithium (n = 1,317), valproic acid (n = 808), carbamazepine (n = 136), and lamotrigine (n = 665). The dose of lithium was correlated with age, body weight, number of episodes, depression and GAF. The dose of valproic acid was correlated with body weight, number of episodes, presence of a rapid cycle and GAF. The dose of carbamazepine was correlated with age, mania, and the presence of a rapid cycle. The dose of lamotrigine was correlated with the number of episodes, depression, mania, psychotic features, and the presence of a rapid cycle. Doses of coadministered mood stabilizers were significantly correlated, except for the combination of valproic acid and lamotrigine.
Conclusion
The dose of mood stabilizers was selectively administered based on several factors, such as age, body composition, current mood status and functioning. Further prospective studies are required to confirm these findings.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers
- Trends in Pharmacotherapy of the Hospitalized Patients with Bipolar Disorder: A Twele-year Naturalistic Study
- Drug-Drug Interactions: Mood Stabilizers and Anti-Anxiety Drugs
- Pharmacological Treatment Strategies for Acute Bipolar Depression
- A Trend of Drug Use in Inpatients with Bipolar Disorder: A 4-Year Naturalistic Study in One Hospital
