Investig Magn Reson Imaging.  2020 Mar;24(1):61-65. 10.13104/imri.2020.24.1.61.

Langerhans Cell Histiocytosis of the Rib of an Adult Female Patient: a Case Report

  • 1Department of Radiology, Chungbuk National University Hospital, Cheongju, Korea
  • 2Department of Pathology, College of Medicine, Chungbuk National University, Cheongju, Korea


Langerhans cell histiocytosis (LCH) is generally considered a childhood disease that exhibits various nonspecific clinical and radiological manifestations that mimic infection or malignancy. Here, we present a case of LCH involving the rib in an adult patient. CT and MRI revealed an expansile lytic lesion with periosteal reaction on the left 8th rib, suggesting a malignant bone tumor. Surgical resection was performed and histopathological examination was consistent with LCH. Owing to its rare occurrence in adults and nonspecific aggressive features, LCH should be included in the differential diagnosis of an aggressive-appearing rib lesion in both adults and children.


Adult; Computed tomography (CT); Langerhans cell histiocytosis (LCH); Magnetic resonance imaging (MRI); Rib
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