Clin Mol Hepatol.
2020 Oct;26(4):618-625. 10.3350/cmh.2020.0142.
Programmed cell death in alcohol-associated liver disease
- Affiliations
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- 1Northern Ohio Alcohol Center, Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, USA
- 2Department of Gastroenterological Surgery, Kumamoto University Hospital, Kumamoto, Japan
- 3Department of Molecular Medicine, Case Western Reserve University, Cleveland, OH, USA
- 4Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, OH, USA
- KMID: 2507982
- DOI: http://doi.org/10.3350/cmh.2020.0142
Abstract
- Alcohol-associated liver disease (ALD), which ranges from mild disease to alcohol-associated hepatitis and cirrhosis, is the most prevalent type of chronic liver disease and a leading cause of morbidity and mortality worldwide. Accumulating evidence reveals that programmed cell death (PCD) plays a crucial role in progression of ALD involving crosstalk between hepatocytes and immune cells. Multiple pathways of PCD, including apoptosis, necroptosis, autophagy, pyroptosis and ferroptosis, are reported in ALD. Interestingly, PCD pathways are intimately linked and interdependent, making it difficult to therapeutically target a single pathway. This review clarifies the multiple types of PCD occurring in liver and focuses on crosstalk between hepatocytes and innate immune cells in ALD.
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