Blood Res.  2020 Sep;55(3):184-187. 10.5045/br.2020.2020175.

Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

Affiliations
  • 1Division of Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea
  • 2Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea

Abstract

No abstract available.


Figure

  • Fig. 1 Changes in values of ANC (bold line) and LDH (dotted line) with time measured from the start of 8th week of delayed intensification chemotherapy. BM study was done on day 8. Table shows hemoglobin and platelet count at specified time points. Abbreviations: ANC, absolute neutrophil count; BM, bone marrow; LDH, lactate dehydrogenase.

  • Fig. 2 Extensive BM necrosis resulting in lack of normal hematopoietic precursors, as shown in both BM aspiration (A, Wright stain, ×400) and biopsy (B, Hematoxylin and eosin stain, ×400).


Reference

1. Nies BA, Kundel DW, Thomas LB, Freireich EJ. 1965; Leukopenia, bone pain, and bone necrosis in patients with acute leukemia: a clinicopathologic complex. Ann Intern Med. 62:698–705. DOI: 10.7326/0003-4819-62-4-698. PMID: 14274834.
2. Janssens AM, Offner FC, Van Hove WZ. 2000; Bone marrow necrosis. Cancer. 88:1769–80. DOI: 10.1002/(SICI)1097-0142(20000415)88:8<1769::AID-CNCR3>3.0.CO;2-H. PMID: 31424633. PMCID: PMC7468619.
Article
3. Khoshnaw NS, Al-Rawi HA, Nore BF. 2012; Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. J Med Case Rep. 6:349. DOI: 10.1186/1752-1947-6-349. PMID: 23057758. PMCID: PMC3492084.
Article
4. Shapiro R, Rizkalla K, Lam S. 2015; Extensive bone marrow necrosis in a case of acute myeloid leukemia transformed from a myeloproliferative neoplasm. Case Rep Oncol. 8:345–8. DOI: 10.1159/000438822. PMID: 26351444. PMCID: PMC4560299.
Article
5. Matsue K, Takeuchi M, Koseki M, Uryu H. 2006; Bone marrow necrosis associated with the use of imatinib mesylate in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. Ann Hematol. 85:542–4. DOI: 10.1007/s00277-005-0071-3. PMID: 16570152.
Article
6. Lakhwani S, Raya JM, González-Brito G, Álvarez-Argüelles H, Brito ML, Hernández-Nieto L. 2011; Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia. Pathology. 43:515–7. DOI: 10.1097/PAT.0b013e3283489087. PMID: 21753723.
Article
7. Ishitsuka K, Shirahashi A, Iwao Y, et al. 2004; Bone marrow necrosis in a patient with acute promyelocytic leukemia during re-induction therapy with arsenic trioxide. Eur J Haematol. 72:280–4. DOI: 10.1111/j.0902-4441.2003.00206.x. PMID: 15089767.
Article
8. Hilal T, Bansal P, Kelemen K, Slack J. 2018; Nivolumab-associated bone marrow necrosis. Ann Oncol. 29:513–4. DOI: 10.1093/annonc/mdx643. PMID: 29351576.
Article
9. Yarali N, Isik M, Arman-Bilir O, Guzelkucuk Z, Oguz-Erdogan AS. 2020; Bone marrow necrosis in a patient following blinatumomab therapy. J Pediatr Hematol Oncol. 42:e167–9. DOI: 10.1097/MPH.0000000000001532. PMID: 31219910.
Article
10. Seki Y, Koike T, Yano M, et al. 2002; Bone marrow necrosis with dyspnea in a patient with malignant lymphoma and plasma levels of thrombomodulin, tumor necrosis factor-alpha, and D-dimer. Am J Hematol. 70:250–3. DOI: 10.1002/ajh.10136. PMID: 12111773.
11. Lee JW, Kim SK, Jang PS, et al. 2016; Treatment of children with acute lymphoblastic leukemia with risk group based intensification and omission of cranial irradiation: a Korean study of 295 patients. Pediatr Blood Cancer. 63:1966–73. DOI: 10.1002/pbc.26136. PMID: 27463364.
Article
12. Badar T, Shetty A, Bueso-Ramos C, et al. 2015; Bone marrow necrosis in acute leukemia: clinical characteristic and outcome. Am J Hematol. 90:769–73. DOI: 10.1002/ajh.24074. PMID: 26017166. PMCID: PMC4546505.
Article
13. Pui CH, Stass S, Green A. 1985; Bone marrow necrosis in children with malignant disease. Cancer. 56:1522–5. DOI: 10.1002/1097-0142(19851001)56:7<1522::AID-CNCR2820560708>3.0.CO;2-B. PMID: 3861229.
Article
14. Shah NR, Landi DB, Kreissman SG, Kulbachi E, Moran C. 2011; Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review. J Pediatr Hematol Oncol. 33:e316–9. DOI: 10.1097/MPH.0b013e318223fe9b. PMID: 21941136.
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