Ann Dermatol.  2020 Oct;32(5):395-401. 10.5021/ad.2020.32.5.395.

Effect of Chrysanthemum zawadskii Extract on Dermal Papilla Cell Proliferation and Hair Growth

• Kim YD
• Pi LQ
• Lee WS

• KMID: 2506991
• DOI: http://doi.org/10.5021/ad.2020.32.5.395

Abstract

Background
Chrysanthemum zawadskii (CZ) belongs to the genus Chrysanthemum, also known as ‘Gu-Jeol-Cho’ in Korea. CZ has been used as herbal remedy to manage cough, hypertensive disorders, pharyngitis, bronchitis, gastroenteritis, pneumonia, bladder diseases and common cold. However, its effect on hair growth has not been documented.
Objective
The aim of present study was to elucidate the beneficial effects of CZ on hair growth.
Methods
Proliferation of follicular dermal papilla (DP) cells from human scalp skin was evaluated by MTT assay. The expression of various molecules in DP cells was checked by western blot assay. Effect of CZ extract on the hair growth was evaluated by hair organ culture and C57BL/6 mice model.
Results
Cultivation of DP cells with CZ extract increased cellular proliferation, increased expression of phosphorylated protein kinase B (p-Akt), p-ERK, B-cell lymphoma 2, and decreased expression of Bax. Treatment of human hair follicles with CZ extract significantly enhanced hair growth. Additionally, CZ markedly shortened telogen period, increased anagen transformation and stimulated hair growth in the animal study.
Conclusion
These results suggest that CZ extract has an effect of promoting hair growth and may therefore be a useful a therapeutic remedy for preventing hair loss.

Keyword

Chrysanthemum zawadskii; Dermal papilla cells; Hair follicle; Hair growth