Radiat Oncol J.  2020 Sep;38(3):207-216. 10.3857/roj.2020.00528.

Total marrow and lymphoid irradiation with helical tomotherapy: a practical implementation report

• Chilukuri S
• Sundar S
• Thiyagarajan R
• Easow J
• Sawant M
• Krishanan G
• Panda PK
• Sharma D
• Jalali R

• KMID: 2506937
• DOI: http://doi.org/10.3857/roj.2020.00528

Abstract

Objective
To standardize the technique; evaluate resources requirements and analyze our early experience of total marrow and lymphoid irradiation (TMLI) as part of the conditioning regimen before allogenic bone marrow transplantation using helical tomotherapy.
Methods
Computed tomography (CT) scanning and treatment were performed in head first supine (HFS) and feet first supine (FFS) orientations with an overlap at mid-thigh. Patients along with the immobilization device were manually rotated by 180° to change the orientation after the delivery of HFS plan. The dose at the junction was contributed by a complementary dose gradient from each of the plans. Plan was to deliver 95% of 12 Gy to 98% of clinical target volume with dose heterogeneity <10% and pre-specified organs-at-risk dose constraints. Megavoltage-CT was used for position verification before each fraction. Patient specific quality assurance and in vivo film dosimetry to verify junction dose were performed in all patients.
Results
Treatment was delivered in two daily fractions of 2 Gy each for 3 days with at least 8-hour gap between each fraction. The target coverage goals were met in all the patients. The average person-hours per patient were 16.5, 21.5, and 25.75 for radiation oncologist, radiation therapist, and medical physicist, respectively. Average in-room time per patient was 9.25 hours with an average beam-on time of 3.32 hours for all the 6 fractions.
Conclusion
This report comprehensively describes technique and resource requirements for TMLI and would serve as a practical guide for departments keen to start this service. Despite being time and labor intensive, it can be implemented safely and robustly.

Keyword

Total marrow lymphoid irradiation; Total marrow irradiation; Tomotherapy; Total body irradiation; Resource requirements; TMI/TMLI