J Korean Geriatr Soc.
2013 Jun;17(2):79-85. 10.4235/jkgs.2013.17.2.79.
Helical Tomotherapy in Elderly Prostate Cancer Patients
- Affiliations
-
- 1Department of Radiation Oncology, Pusan National University School of Medicine, Busan, Korea. jihonam@hanmail.net
- 2Department of Radiation Oncology, Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
- 3Department of Radiation Oncology, Pusan National University Yangsan Hospital, Yangsan, Korea.
- KMID: 2015216
- DOI: http://doi.org/10.4235/jkgs.2013.17.2.79
Abstract
- BACKGROUND
Helical tomotherapy is a new form of image-guided intensity modulated radiation therapy that may improve local control and decrease radiation toxicity. The aim of this study was to evaluate if high-dose helical tomotherapy is tolerated by patients aged 75 years or older and if the side effects are comparable with those experienced by younger patients.
METHODS
Between January 2011 and August 2012, patients with prostate cancer who underwent helical tomotherapy without elective pelvic irradiation as definitive aim were reviewed and divided into two age groups: > or =75 years and <75 years. Acute genitourinary (GU) and lower gastrointestinal (GI) toxicities between the two groups were compared.
RESULTS
Twenty patients aged 75 years or older and 23 patients younger than 75 years were evaluated. Radiotherapy was administered to a total dose of 76-78Gy in 38-39 fractions or 70Gy in 28 fractions. There was no grade 3 or 4 acute toxicity and no grade 2 acute lower GI symptom, but the patients complained of grade 2 acute GU toxicity, 25.0% for the older group and 13.0% for the younger group. There was no significant difference in the rate of acute toxicity between the age groups. Hypofractionation showed a significant association with higher grade 2 acute GU toxicity (p=0.024) with the grade 2 acute GU toxicity having no significant correlation with T-stage, Gleason score, prostate specific antigen level, androgen deprivation therapy, and comorbidities.
CONCLUSION
High-dose helical tomotherapy to the prostate without pelvic irradiation was well tolerated by elderly prostate cancer patients 75 years and older.
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