J Clin Neurol.
2020 Apr;16(2):292-303. 10.3988/jcn.2020.16.2.292.
South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial
- Park HK
1 - Jeong JH1
- Moon SY2
- Park YK3
- Hong CH4
- Na HR5
- Song HS6
- Lee SM2
- Choi M7
- Park KW8
- Kim BC9
- Cho SH9
- Chun BO6
- Choi SH10
- Affiliations
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- 1Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea.
- 2Department of Neurology, Ajou University School of Medicine, Suwon, Korea.
- 3Department of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University, Suwon, Korea.
- 4Department of Psychiatry, Ajou University School of Medicine, Suwon, Korea.
- 5Department of Neurology, Bobath Memorial Hospital, Seongnam, Korea.
- 6Department of Sports Sciences, Korea Institute of Sports Science, Seoul, Korea.
- 7Department of Physical Education, Kookmin University, Seoul, Korea.
- 8Department of Neurology, Dong-A University College of Medicine, Busan, Korea.
- 9Department of Neurology, Chonnam National University Medical School, Gwangju, Korea.
- 10Department of Neurology, Inha University School of Medicine, Incheon, Korea.
- KMID: 2506822
- DOI: http://doi.org/10.3988/jcn.2020.16.2.292
Abstract
- Background and Purpose
The prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to be disseminated to elderly Koreans throughout the country. We have developed programs of the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), which consists of a facility-based multidomain intervention (FMI) program and a home-based multidomain intervention (HMI) program suitable for elderly Koreans. We aim to determine the feasibility of the SUPERBRAIN programs before a large-scale randomized controlled trial.
Methods
We will recruit 150 participants among those without dementia aged 60–79 years with at least 1 modifiable dementia risk factor. They will be randomly assigned in a 1:1:1 ratio to the FMI, HMI, and the waiting-list control arm. The 6-month multidomain intervention consists of management of metabolic and vascular risk factors, cognitive training and social activity, physical exercise, nutritional guidance, and motivational enhancement programs. The primary outcomes are adherence and retention rates and changes in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to the study end. The main secondary outcomes are disability, depressive symptoms, quality of life, vascular risk factors, physical performance, nutritional assessment, and motivation questionnaire. There will be an exploratory evaluation of neurotrophic, neurodegeneration, and neuroinflammation factors, microbiome, telomere length, electroencephalography, and neuroimaging measures.
Conclusions
The results obtained will provide information on the applicability of these multidomain intervention programs to at-risk elderly people.
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