Korean J Radiol.  2020 Oct;21(10):1187-1195. 10.3348/kjr.2019.0983.

Sonographic Assessment of the Extent of Extrathyroidal Extension in Thyroid Cancer

• Chung SR
• Baek JH
• Choi YJ
• Sung TY
• Song DE
• Kim TY
• Lee JH

• KMID: 2506451
• DOI: http://doi.org/10.3348/kjr.2019.0983

Abstract

Objective
This study aimed to determine the sonographic features suggestive of extrathyroidal extension (ETE) of thyroid cancers.
Materials and Methods
We retrospectively reviewed the sonographic images of 1656 consecutive patients who had undergone thyroidectomy in 2017. The diagnostic performance of sonographic features suggestive of ETE was evaluated using operation and histopathologic reports. Sonographic features for gross ETE to the strap muscle and minor ETE were assessed for thyroid cancer abutting the anterolateral thyroid capsule. Sonographic features for tracheal invasion were assessed according to whether the angle between the tumor and the trachea was an acute, right, or obtuse angle. Sonographic features for recurrent laryngeal nerve (RLN) invasion were assessed based on the association between the tumor and tracheoesophageal groove (TEG) as preserved normal tissue, abutting or protruding into the TEG.
Results
ETE was observed in 783 patients (47.3%), including 123 patients with gross ETE (7.4% [strap muscle, n = 97; RLN, n = 24; and trachea, n = 14]) and 660 patients with minor ETE (39.9%). Regarding the diagnosis of gross and minor ETE to the strap muscle, sonographic features of replacement of the strap muscle and capsular disruption showed the highest positive predictive value (75.9% and 58.5%, respectively). Thyroid cancer forming an obtuse angle with the trachea had the highest sensitivity for the diagnosis of tracheal invasion (85.7%), and thyroid cancer protrusion into the TEG showed the highest sensitivity for the diagnosis of RLN (83.3%).
Conclusion
Sonography is considered beneficial in the diagnosis of ETE to the strap muscle, trachea, and RLN. Assessment of ETE is important for the accurate staging of thyroid cancer, which in turn determines the extent of surgery or whether active surveillance is appropriate or not.

Keyword

Thyroid neoplasms; Ultrasonography; Diagnostic imaging; Neoplasm staging; Preoperative care